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Nanozyme-based dual-signal sensing system for colorimetric and photothermal detection of AChE activity in the blood of liver-injured mice

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成果类型:
期刊论文
作者:
He, Chang;Ke, Zhenyi;Liu, Kai;Peng, Jiasheng;Yang, Qinghui;...
通讯作者:
Feng, Guangfu(GuangfuFeng@hunau.edu.cn);Fang, Jun(fangjun1973@hunau.edu.cn)
作者机构:
[He, Chang; Feng, Guangfu; Wang, Lixiang; Ke, Zhenyi; Liu, Kai; Yang, Qinghui; Peng, Jiasheng; Fang, Jun] Hunan Agr Univ, Sch Biosci & Biotechnol, Changsha 410128, Peoples R China.
通讯机构:
[Guangfu Feng; Jun Fang] S
School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China<&wdkj&>School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China
语种:
英文
关键词:
AChE;CeO2 nanoparticles;Photothermal effect;Organophosphorus;POCT;Liver injury
期刊:
Analytical and Bioanalytical Chemistry
ISSN:
1618-2642
年:
2023
卷:
415
期:
14
页码:
2655-2664
基金类别:
This work was supported by the National Natural Science Foundation of China (numbers 31672457, 22004035), China Postdoctoral Science Foundation (numbers 2020TQ0094, 2020M682565), Hunan Provincial Science and Technology Department (numbers 2018WK4025, 2020NK2004, 2020ZL2004, 2021JJ40230, 2021JJ30008), the Double first-class construction project of Hunan Agricultural University (numbers SYL201802003, YB2018007, CX20190497), the science and technology innovation Program of Hunan Province (number 2020RC2054).
机构署名:
本校为第一机构
院系归属:
生物科学技术学院
摘要:
Acetylcholinesterase (AChE), a crucial enzyme related to liver function, is involved in numerous physiological processes such as neurotransmission and muscular contraction. The currently reported techniques for detecting AChE mainly rely on a single signal output, limiting their high-accuracy quantification. The few reported dual-signal assays are challenging to implement in dual-signal point-of-care testing (POCT) because of the need for large instruments, costly modifications, and trained operators. Herein, we report a colorimetric and photot...

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