The protective effects of DL-Selenomethionine against T-2/HT-2 toxins-induced cytotoxicity and oxidative stress in broiler hepatocytes.

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成果类型：

期刊论文

作者：

Yang, Lingchen;Tu, Di;Wang, Naidong;Deng, Zhibang;Zhan, Yang;...

通讯作者：

Guo, Shiyin;Wang, Aibing

作者机构：

[Yang, Lingchen; Liu, Wei; Wang, Aibing; Tu, Di; Tan, Lei; Li, Yalan; Hu, Yi; Liu, Tanbin] Hunan Agr Univ HUNAU, LAMFG, Key Lab Anim Vaccine & Prot Engn, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Wang, Naidong; Zhan, Yang; Deng, Zhibang] Hunan Agr Univ HUNAU, LFP, Key Lab Anim Vaccine & Prot Engn, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Guo, Shiyin] HUNAU, Coll Food Sci & Technol, Changsha 410128, Hunan, Peoples R China.

[Guo, Shiyin; Wang, AB] Hunan Agr Univ, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Guo, SY; Wang, AB] H

Hunan Agr Univ, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Cytotoxicity;DL-Selenomethionine;Hepatocytes;Oxidative stress;Protective effects;T-2/HT-2 toxins

期刊：

Toxicology in Vitro

ISSN：

0887-2333

年：

2019

卷：

页码：

137-146

DOI：

10.1016/j.tiv.2018.09.016

基金类别：

Acknowledgments This work was supported by: General Program of National Natural Science Foundation of China (Grants No. 31802252); General Program of National Natural Science Foundation of China (Grants No. 31571432); Hunan Provincial Natural Science Foundation of China (Grant No. 2015JC3097); Research Foundation of Education Bureau of Hunan Province, China (Grant No. 15K054). Support was also provided by “Shennong” Scholar funding to Aibing Wang.

机构署名：

本校为通讯机构

院系归属：

动物医学院

食品科学技术学院

摘要：

T-2 and HT-2 toxins can cause cytotoxicity and oxidative stress in animals, while DL-Selenomethionine plays an important role in preventing oxidative stress and improving cell viability. However, the role of DL-Selenomethionine in T-2/HT-2 toxins-induced cell damage is still unknown. In this study, we investigated whether DL-Selenomethionine plays a protective role against T-2/HT-2-induced cytotoxicity and oxidative stress in primary hepatocytes. Our results demonstrated that T-2/HT-2 toxins-exposed broiler hepatocytes exhibited significantly decreased cell viability and intracellular glutathi...

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The protective effects of DL-Selenomethionine against T-2/HT-2 toxins-induced cytotoxicity and oxidative stress in broiler hepatocytes.

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