Macleaya cordata isoquinoline alkaloids attenuate Escherichia coli lipopolysaccharide-induced intestinal epithelium injury in broiler chickens by co-regulating the TLR4/MyD88/NF-κB and Nrf2 signaling pathways

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期刊论文

作者：

Liu, Yang;Han, Kai;Liu, Hua;Jia, Gang;Comer, Luke;...

通讯作者：

Li, Y

作者机构：

[Jiang, Shuzhen; Wang, Guanlin; Yang, Weiren; Liu, Yang; Han, Kai; Pan, Zizhu; Li, Yang; Zhao, Yiqian; Jiao, Ning; Huang, Libo] Minist Agr & Rural Affairs, Dept Anim Sci & Vet Med, Key Lab Efficient Utilizat Non Grain Feed Resource, Tai An, Peoples R China.

[Liu, Yang; Jia, Gang] Sichuan Agr Univ, Inst Anim Nutr, Key Lab Anim Dis Resistance Nutr China, Minist Educ, Chengdu, Sichuan, Peoples R China.

[Liu, Hua] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Peoples R China.

[Comer, Luke; Li, Yang] Dept Biosyst, Div Anim & Human Hlth Engn, Nutr & Anim Microbiota Ecosyst Lab, KU Leuven, Heverlee, Belgium.

通讯机构：

[Li, Y ] M

Minist Agr & Rural Affairs, Dept Anim Sci & Vet Med, Key Lab Efficient Utilizat Non Grain Feed Resource, Tai An, Peoples R China.

Dept Biosyst, Div Anim & Human Hlth Engn, Nutr & Anim Microbiota Ecosyst Lab, KU Leuven, Heverlee, Belgium.

语种：

英文

关键词：

Macleaya cordata isoquinoline alkaloid;broiler;intestinal epithelium injury;intestinal inflammation;lipopolysaccharide;oxidative stress

期刊：

FRONTIERS IN IMMUNOLOGY

ISSN：

1664-3224

年：

2024

卷：

页码：

1335359

DOI：

10.3389/fimmu.2023.1335359

基金类别：

National Key Research and Development Program of China [2023YFD1301605]; China Scholarship Council (CSC) [202209135002]

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

摘要：

This study sought to explore the effects and potential mechanisms of dietary supplementation with isoquinoline alkaloids (IA) from Macleaya cordata to alleviate lipopolysaccharide (LPS)-induced intestinal epithelium injury in broilers. A total of 486 1-day-old broilers were assigned at random to a control (CON) group, LPS group, and LPS+IA group in a 21-d study. The CON and LPS groups received a basal diet, while the LPS+IA group received a basal diet supplemented with 0.6 mg/kg IA. At 17, 19, and 21 days of age, the LPS and LPS+BP groups were ...

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Macleaya cordata isoquinoline alkaloids attenuate Escherichia coli lipopolysaccharide-induced intestinal epithelium injury in broiler chickens by co-regulating the TLR4/MyD88/NF-κB and Nrf2 signaling pathways

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