Effect and mechanism of edible oil co-digestion on the bioaccessibility and bioavailability of ursolic acid

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成果类型：

期刊论文

作者：

Liu, Yugang;Xia, Huiping;Guo, Shiyin;Li, Peiwang;Qin, Si;...

通讯作者：

Shi, Meng;Zeng, CX

作者机构：

[Zeng, Chaoxi; Zeng, CX; Xia, Huiping; Qin, Si; Shi, Meng; Liu, Yugang; Guo, Shiyin] Hunan Agr Univ, Coll Food Sci & Technol, Dept Food Sci & Technol, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.

[Zeng, Chaoxi; Guo, Shiyin] Hunan Agr Univ, Hunan Rapeseed Oil Nutr Hlth & Deep Dev Engn Techn, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.

[Li, Peiwang] Hunan Acad Forestry, State Key Lab Utilizat Woody Oil Resource, 658 Shaoshan South Rd, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Zeng, CX ; Shi, M] H

Hunan Agr Univ, Coll Food Sci & Technol, Dept Food Sci & Technol, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Bioaccessibility;Bioavailability;Caco-2 cell monolayer;Simulated digestion in vitro;Ursolic acid

期刊：

Food Chemistry

ISSN：

0308-8146

年：

2023

卷：

423

页码：

136220

DOI：

10.1016/j.foodchem.2023.136220

基金类别：

This study was funded by the National Key Research and Development Program of China ( 2019YFC1604903 ), the Natural Science Foundation of Hunan Province ( 2021JJ30321 ) and Key Research and Development Project of Hunan Province ( 2022NK2033 ).

机构署名：

本校为第一且通讯机构

院系归属：

食品科学技术学院

摘要：

Ursolic acid (UA), a pentacyclic triterpenoid, has gained attentions due to its various health-promoting benefits, but exhibits poor bioavailability. This could be enhanced by changing the food matrix of UA in which it is present. In this study, several UA systems were constructed to investigate the bioaccessibility and bioavailability of UA in combination with in vitro simulated digestion and Caco-2 cell models. The results showed that the bioaccessibility of UA was significantly improved after adding rapeseed oil. Caco-2 cell models showed th...

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Effect and mechanism of edible oil co-digestion on the bioaccessibility and bioavailability of ursolic acid

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