Objective: To investigate the etiology of Major Depressive Disorder(MDD), we explored the relationship of anhedonia, stress and neuroticism in MDD patients. Methods: Investigation was conducted among 84 MDD patients and 75 healthy controls by using the Temporal Experience of Pleasure Scale(TEPS), Five-Factor Inventory-Neuroticism(FFI-N), Beck Depression Inventory(BDI) and Live Events Scale(LES). Results: Compared with healthy controls, MDD patients ex- hibited significantly lower scores on anticipatory pleasure, consummatory pleasure(P