Quantifying the Degree of Aggregation from Fluorescent Dye-Conjugated DNA Probe by Single Molecule Photobleaching Technology for the Ultrasensitive Detection of Adenosine

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成果类型：

期刊论文

作者：

Shi, Xingbo*;He, Yu;Gao, Wenli;Liu, Xiaoying;Ye, Zhongju;...

通讯作者：

Shi, Xingbo;Xiao, Lehui

作者机构：

[Shi, Xingbo; Gao, Wenli; He, Yu] Hunan Agr Univ, Coll Food Sci & Technol, Hunan Prov Key Lab Food Sci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

[Shi, Xingbo] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

[Liu, Hua; Ye, Zhongju; Xiao, Lehui] Nankai Univ, Coll Chem, Tianjin Key Lab Biosensing & Mol Recognit, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China.

[Liu, Xiaoying] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Shi, Xingbo] H

[Xiao, Lehui] N

Hunan Agr Univ, Coll Food Sci & Technol, Hunan Prov Key Lab Food Sci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

Nankai Univ, Coll Chem, Tianjin Key Lab Biosensing & Mol Recognit, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China.

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2018

卷：

期：

页码：

3661-3665

DOI：

10.1021/acs.analchem.7b05317

基金类别：

National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [21522502, 31301484]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2015JJ3082]; Open Foundation of State Key Laboratory of Chemo/Biosensing and Chemometrics [Z2015025]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学技术学院

理学院

摘要：

In this work, we demonstrated a single molecule photobleaching-based strategy for the ultrasensitive detection of adenosine. A modified split aptamer was designed to specifically recognize individual adenosine molecules in solution. The specific binding of dye-labeled short strand DNA probes onto the elongated aptamer strand in the presence of adenosine resulted in a concentration-dependent self-aggregation process. The degree-of-aggregation (DOA) of the short DNA probes on the elongated aptamer strand could then be accurately determined based ...

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Quantifying the Degree of Aggregation from Fluorescent Dye-Conjugated DNA Probe by Single Molecule Photobleaching Technology for the Ultrasensitive Detection of Adenosine

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