The immune responses elicited by six recombinant antigens of Mycoplasma hyopneumoniae in mice

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成果类型：

期刊论文

作者：

Li, Shiyang;Yin, Ruiru;Xiong, Qiyan;Liu, Maojun;Wang, Jia;...

通讯作者：

Feng, Zhixin;Yu, YF

作者机构：

[Feng, Zhixin; Liu, Maojun; Yin, Ruiru; Zhang, Zhenzhen; Feng, ZX; Yu, Yanfei; Xiong, Qiyan; Shao, Guoqing; Wang, Jia; Li, Shiyang; Yu, YF] Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr & Rural Affairs, Nanjing, Peoples R China.

[Deng, Zhibang; Li, Shiyang] Hunan Agr Univ, Coll Vet Med, Changsha, Peoples R China.

[Feng, Zhixin; Liu, Maojun; Yin, Ruiru; Zhang, Zhenzhen; Yu, Yanfei; Xiong, Qiyan; Shao, Guoqing; Wang, Jia; Li, Shiyang] Guotai Taizhou Ctr Technol Innovat Vet Biol, Taizhou, Peoples R China.

[Feng, Zhixin; Liu, Maojun; Yin, Ruiru; Yu, Yanfei; Xiong, Qiyan] Nanjing Agr Univ, Coll Vet Med, Nanjing, Peoples R China.

[Yu, Yanfei; Xiong, Qiyan] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Peoples R China.

通讯机构：

[Feng, ZX; Yu, YF ] J

Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr & Rural Affairs, Nanjing, Peoples R China.

语种：

英文

关键词：

CD8+ T cells;Cellular immunity;Mucosal immune response;Mycoplasma hyopneumoniae;Subunit vaccine;Th17-type immune response

期刊：

Veterinary microbiology

ISSN：

0378-1135

年：

2024

卷：

299

页码：

110295

DOI：

10.1016/j.vetmic.2024.110295

基金类别：

National Key Research and Development Program of China [2022YFD1800903]; National Natural Science Foundation of China [32172860, 32102675]; Jiangsu Association for Science and Technology Youth Talent Support Program [JSTJ-2023-XH031]

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

Mycoplasma hyopneumoniae (M. hyopneumoniae) is the causative agent of swine enzootic pneumonia, resulting in substantial economic losses in global pig farming. Although vaccination is the primary strategy for controlling M. hyopneumoniae infection, current vaccines fall short in preventing transmission of this pathogen or protecting the body from secondary infection. This study aimed to assess the immunogenicity of six recombinant antigens (P97R1, P46, GAPDH, PdhA, DnaK, and EF-Tu) of M. hyopneumoniae through intramuscular immunization in mice. The results showed that the six antigens elicited...

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The immune responses elicited by six recombinant antigens of Mycoplasma hyopneumoniae in mice

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