Cadmium suppresses the proliferation of piglet Sertoli cells and causes their DNA damage, cell apoptosis and aberrant ultrastructure

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Ming;He, Zuping*;Wen, Lixin;Wu, Jing;Yuan, Liyun;...

通讯作者：

He, Zuping

作者机构：

[Wu, Jing; Deng, Sijun; Zhu, Li; Yuan, Liyun; Wen, Lixin; Guo, Chengzhi; Lu, Yin; Yuan, Hui; Zhang, Ming] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[He, Zuping] Georgetown Univ, Dept Biochem & Mol & Cellular Biol, Med Ctr, Washington, DC 20057 USA.

[Zhang, Ming] Jiangxi Biotech Vocat Coll, Nanchang 330200, Jiangxi, Peoples R China.

[He, Zuping] Georgetown Univ, Dept Biochem & Mol & Cellular Biol, Med Ctr, 3900 Reservoir Rd NW, Washington, DC 20057 USA.

通讯机构：

[He, Zuping] G

Georgetown Univ, Dept Biochem & Mol & Cellular Biol, Med Ctr, 3900 Reservoir Rd NW, Washington, DC 20057 USA.

语种：

英文

关键词：

Cadmium;Sertoli Cell;Seminiferous Tubule;Male Germ Cell;Spermatogonial Stem Cell

期刊：

Reproductive Biology and Endocrinology

ISSN：

1477-7827

年：

2010

卷：

期：

页码：

1-12

DOI：

10.1186/1477-7827-8-97

基金类别：

Department of Education of Hunan Province, China [03A020]

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

Very little information is known about the toxic effects of cadmium on somatic cells in mammalian testis. The objective of this study is to explore the toxicity of cadmium on piglet Sertoli cells. Sertoli cells were isolated from piglet testes using a two-step enzyme digestion and followed by differential plating. Piglet Sertoli cells were identified by oil red O staining and Fas ligand (FasL) expression as assayed by immunocytochemistry and expression of transferrin and androgen binding protein by RT-PCR. Sertoli cells were cultured in DMEM/F12 supplemented with 10% fetal calf serum in the ab...

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Cadmium suppresses the proliferation of piglet Sertoli cells and causes their DNA damage, cell apoptosis and aberrant ultrastructure

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