Proteomic alterations in the plasma of Beagle dogs induced by Toxocara canis infection

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成果类型：

期刊论文

作者：

Zheng, Wen-Bin;Zou, Yang;He, Jun-Jun*;Liu, Guo-Hua;Hu, Min-Hu;...

通讯作者：

He, Jun-Jun;Zhu, Xing-Quan

作者机构：

[He, Jun-Jun; Zheng, Wen-Bin; Zou, Yang; Zhu, Xing-Quan; Zhu, XQ] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Vet Parasitol Gansu Prov, State Key Lab Vet Etiol Biol, Lanzhou 730046, Gansu, Peoples R China.

[Zheng, Wen-Bin; Liu, Guo-Hua] Hunan Agr Univ, Coll Vet Med, Hunan Prov Key Lab Prot Engn Anim Vaccines, Changsha 410128, Hunan, Peoples R China.

[Zhu, Xing-Quan] Shanxi Agr Univ, Coll Vet Med, Taigu 030801, Shanxi, Peoples R China.

[Hu, Min-Hu] Guangzhou Gen Pharmaceut Res Inst Co Ltd, Natl Canine Lab Anim Resource Ctr, Guangzhou 510240, Guangdong, Peoples R China.

通讯机构：

[He, JJ; Zhu, XQ] C

Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Vet Parasitol Gansu Prov, State Key Lab Vet Etiol Biol, Lanzhou 730046, Gansu, Peoples R China.

语种：

英文

关键词：

Beagle dog;DIA;Proteomics;Toxocara canis;Toxocariasis

期刊：

Journal of Proteomics

ISSN：

1874-3919

年：

2021

卷：

232

页码：

104049

DOI：

10.1016/j.jprot.2020.104049

基金类别：

Acknowledgements Project support are provided by the Elite Program of Chinese Academy of Agricultural Sciences, and the Agricultural Science and Technology Innovation Program (ASTIP) (grant no. CAAS-ASTIP-2016-LVRI-03). The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

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本校为其他机构

院系归属：

动物医学院

摘要：

Toxocara canis causes ocular larva migrans and visceral larva migrans in humans. Knowledge about the molecular mechanism of T. canis-hosts interaction is limited. The proteomic alterations in the plasma of Beagle dogs induced by T. canis infection were studied by the quantitative mass spectrometry-based data-independent acquisition (DIA). 418, 414 and 411 plasma proteins were identified at 24h post-infection (hpi), 96 hpi and 36days post-infection (dpi), including 6, 5 and 23 proteins with differential abundance, respectively. At 24 hpi, the altered proteins, retinoic acid receptor responder p...

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Proteomic alterations in the plasma of Beagle dogs induced by Toxocara canis infection

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