Emergence of a Novel Recombinant Pseudorabies Virus Derived From the Field Virus and Its Attenuated Vaccine in China

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tan, Lei;Yao, Jun;Lei, Lei;Xu, Kaiwen;Liao, Fan;...

通讯作者：

Wang, A.

作者机构：

[Wang, Aibing; Xu, Kaiwen; Liao, Fan; Yang, Lincheng; Tan, Lei; Lei, Lei; Duan, Deyong] Hunan Agr Univ HUNAU, Coll Vet Med, Hunan Prov Key Lab Prot Engn Anim Vaccines, Lab Anim Dis Prevent & Control & Anim Model, Changsha, Peoples R China.

[Yao, Jun; Yang, Shibiao] Yunnan Anim Sci & Vet Inst, Yunnan Trop & Subtrop Anim Virus Dis Lab, Kunming, Peoples R China.

[Shu, Xianghua] Yunnan Agr Univ, Coll Anim Med, Kunming, Peoples R China.

[Wang, Aibing] PCB Biotechnol LLC, Rockville, MD 20852 USA.

通讯机构：

Lab of Animal Disease Prevention and Control and Animal Model, Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines, College of Veterinary Medicine, Hunan Agricultural University (HUNAU), Changsha, China

语种：

英文

关键词：

pseudorabies virus;Natural recombination;genetic analysis;pathogenicity;China

期刊：

Frontiers in Veterinary Science

ISSN：

2297-1769

年：

2022

卷：

页码：

872002

DOI：

10.3389/fvets.2022.872002

基金类别：

This work was supported by the General Program of the National Natural Science Foundation of China (Grants No. 31571432/31802252), the National Key Research and Development Program of China (No. 2017YFD0501800), the Major Specialized Projects of Yunnan Science and Technology (No. 202102AE090007), the Hunan Provincial Natural Science Foundation of China (2020JJ4041), the Postgraduate Scientific Research Innovation Project of Hunan Province (CX20200659), Support was also provided by Furong Scholar funding to AW.

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

The occurrence of pseudorabies (PR) caused by the PR virus (PRV) causes huge economic losses to the pig industry in China. Moreover, the potential threat of PRV to humans' health has received wide attention recently. The prevalence of two PRV genotypes and the application of their corresponding live attenuated vaccines increase the recombination possibility. In the present study, a novel recombinant PRV strain designed as HN-2019 was isolated from one sick piglet in Hunan province, China, its genetic features and pathogenicity were further investigated. The results showed that the glycoprotein...

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Emergence of a Novel Recombinant Pseudorabies Virus Derived From the Field Virus and Its Attenuated Vaccine in China

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