Disease resistance varies among fish species. The genetic factors contributing to disease resistance are largely unknown. Here, by comparative analysis on the disease resistance trait of grass carp (Ctenopharyngodon idellus, Ci) and barbel chub (Squaliobarbus curriculus, Sc), we report that the genes encoding SIDT2, MDA5 and IFN are associated with the resistance to viral infection. We identified the amino acid difference of SIDT2s, the existing or lacking of dsRNA binding loci in the carboxy-terminal domain (CTD) of MDA5s, and the promoter difference of ifn2s between the two fish species. Bot...
