l-Theanine prevents ETEC-induced liver damage by reducing intrinsic apoptotic response and inhibiting ERK1/2 and JNK1/2 signaling pathways

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成果类型：

期刊论文

作者：

Gong, Zhihua;Liu, Qiuling;Lin, Ling;Deng, Yanli;Cai, Shuxian;...

通讯作者：

Xiao, Wenjun;Xiong, Shuo;Chen, Dong

作者机构：

[Xiao, WJ; Xiong, S; Chen, D; Gong, Zhihua; Xiong, Shuo; Liu, Zunying; Chen, Dong; Xiao, Wenjun; Zhang, Sheng; Liu, Qiuling; Cai, Shuxian; Lin, Ling; Deng, Yanli] Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct In, Changsha 410128, Hunan, Peoples R China.

[Gong, Zhihua; Xiong, Shuo; Liu, Zunying; Chen, Dong; Xiao, Wenjun; Zhang, Sheng; Liu, Qiuling; Cai, Shuxian; Lin, Ling; Deng, Yanli] Hunan Agr Univ, Minist Educ, Key Lab Tea Sci, Changsha 410128, Hunan, Peoples R China.

[Xiong, Shuo] Chinese Acad Sci, Inst Bont, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China.

[Deng, Yanli] Guizhou Univ, Tea Coll, Guiyang 550025, Guizhou, Peoples R China.

[Chen, Dong] Guangdong Acad Agr Sci, Tea Res Inst, Guangzhou 510640, Guangdong, Peoples R China.

通讯机构：

[Xiao, WJ; Xiong, S; Chen, D] H

Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct In, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis response;ETEC;Hepatic injury;l-Theanine

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2018

卷：

818

页码：

184-190

DOI：

10.1016/j.ejphar.2017.10.050

基金类别：

This work was financially supported by The National Key Research and Development Program of China (grant number 2017YFD0400803 ) and Science and Technology Major Project of Hunan Province , China (grant number 2017NK1020 ).

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

L-Theanine (LTA; γ-glutamylethylamide), a peculiar non-protein-derived amino acid isolated from tea, is widely used as a functional ingredient and dietary supplement. L-Theanine has been confirmed to have hepatoprotective effects, but the underlying mechanism remains unknown. This study investigated the protective effect of L-Theanine-in vivo, using an enterotoxigenic Escherichia coli (ETEC)-infected mouse model. L-Theanine significantly decreased the elevated serum activities of both aspartate aminotransferase (AST) and alanine aminotransfera...

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l-Theanine prevents ETEC-induced liver damage by reducing intrinsic apoptotic response and inhibiting ERK1/2 and JNK1/2 signaling pathways

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