期刊论文

中文

遗传

0253-9772

2018

40

4

305-314

10.16288/j.yczz.17-394

湖南省***计划项目 湖南省畜禽安全生产协同创新中心项目资助

本校为第一机构

自然和人工选择、地理隔离和遗传漂移等原因使动物基因组中许多位点的等位基因频率在群体间会产生差异。源于不同品种(祖先)杂交(交配)的动物个体,其基因组与这些品种(祖先)的基因频率(基因型)会存在一定的相关性。因此采用合适的统计模型和分析方法,可以估计出每个品种(祖先)对于个体基因组的遗传贡献比例,又称为个体的基因组品种构成(genomic breed composition, GBC)。本文介绍了利用SNP芯片数据估计动物个体GBC的原理、方法及步骤,并且通过对198头待鉴定的日本红毛和牛GBC的评估,演示了用回归模型和混合分布模型估计动物个体GBC的具体步骤,其中包括SNP子集的筛选、参考群体中动物个体选择以...

Natural and artificial selection, geographical segregation and genetic drift can result in differentiation of allelic frequencies of single nucleotide polymorphism (SNP) at many loci in the animal genome. For individuals whose ancestors originated from different populations, their genetic compositions exhibit multiple components correlated with the genotypes or allele frequencies of these breeds or populations. Therefore, by using an appropriate statistical method, one can estimate the genomic contribution of each breed (ancestor) to the genome of each individual animal, which is referred to a...