Magnolol-loaded polydopamine-chitosan coated pH-responsive nanoparticles for alleviation of ulcerative colitis

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成果类型：

期刊论文

作者：

Mu, Guohao;Peng, Fang;Zhang, Ziyin;Brameld, John M.;Rose, Peter;...

通讯作者：

He, X;Jiang, ZJ;Tang, BC

作者机构：

[Mu, Guohao; Tang, Bencan] Univ Nottingham Ningbo China, Nottingham Ningbo China Beacons Excellence Res &, 211 Xingguang Rd, Ningbo, Peoples R China.

[Mu, Guohao; Tang, Bencan] Univ Nottingham Ningbo China, Key Lab Carbonaceous Waste Proc & Proc Intensific, Dept Chem & Environm Engn, 199 Taikang East Rd, Ningbo 315100, Peoples R China.

[He, Xi; Peng, Fang; He, X] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.

[Jiang, Zhi-jiang; Zhang, Ziyin; Jiang, ZJ] NingboTech Univ, Sch Biol & Chem Engn, Ningbo 315100, Peoples R China.

[Brameld, John M.; Rose, Peter] Univ Nottingham, Sch Biosci, Sutton Bonington Campus, Loughborough LE12 5RD, Leics, England.

通讯机构：

[Tang, BC ] 1

[He, X ] H

[Jiang, ZJ ] N

Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.

NingboTech Univ, Sch Biol & Chem Engn, Ningbo 315100, Peoples R China.

语种：

英文

关键词：

Polydopamine;magnolol;Ulcerative colitis

期刊：

Journal of Drug Delivery Science and Technology

ISSN：

1773-2247

年：

2024

卷：

101

DOI：

10.1016/j.jddst.2024.106151

基金类别：

National Natural Science Foundation of China [22171153, 21502101]; Ningbo Science and Technology Bureau under CM2025 programme [2020Z092]; Ningbo Natural Science Foundation Programme [2022J171]; Ministry of Science and Technology of the People's Republic of China under funding scheme National Key R&D Program of Intergovernmental Kay Projects [2018YFE0101700]; Ningbo Municipal Key Laboratory on Clean Energy Conversion Technologies [2014A22010]; Zhejiang Provincial Key Laboratory for Carbonaceous Waste Processing and Process Intensification Research - Zhejiang Provincial Department of Science and Technology [2020E10018]

机构署名：

本校为通讯机构

院系归属：

动物科学技术学院

摘要：

This study designed and developed a novel three-layer electrostatic, slow-releasing nanoparticle drug delivery system for the treatment of ulcerative colitis. The nanoparticles were composed of layers of zein-based polydopamine, chitosan and cellulose acetate phthalate to form a polyelectrolyte multilayer core-shell nanoparticle structure. The anti-inflammatory natural product magnolol was chosen to be the model drug for the study. The nanoparticles (260.50 +/- 23.90 nm) were prepared with layer-by-layer coating and then assessed in vitro and in vivo using a mouse model of ulcerative colitis. ...

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Magnolol-loaded polydopamine-chitosan coated pH-responsive nanoparticles for alleviation of ulcerative colitis

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