期刊论文

Imprinted Genes: Regulatory Mechanism on Development of Mammalian Embryos and Placenta

中文

动物营养学报

1006-267X

2016

28

6

1661-1669

10.3969/j.issn.1006-267x.2016.06.005

湖南省自然科学基金项目（13JJ6102） 中国科学院外籍青年科学家计划（2013Y2GA0010）

本校为第一机构

印记基因在调控哺乳动物的众多生命进程中发挥着重要作用,尤其是在生命形成初期,印记基因通过表观遗传修饰决定等位基因的表达和沉默,调节着胚胎和胎盘的生长发育。印记基因在胎盘和胚胎中的表达紊乱与胎儿生长受限、发育停止以及甲状腺脱毒症等密切相关,因此深入探索印记基因对胚胎和胎盘发育的调节机理对于哺乳动物胎儿宫内发育迟缓、出生缺陷以及后期疾病的预防具有重要的指导意义。本文综述了印记基因的主要特点、性腺中印记的擦除、重建与表观遗传修饰及印记基因调控哺乳动物胚胎和胎盘发育的最新研究进展。

Imprinted genes play a significant role in the regulation of life processes in mammals. In the early stage of life, imprinted genes adjust allele's expression or silence with epigenetic modification and subsequently regulate the growth of embryos and placenta. The abnormal expressions of imprinted genes are closely related to fetal growth restriction, developmental arrest and thyroid detoxification in the embryos and placenta, so it is important to explore the regulation mechanisms of imprinted genes on the development of embryos and placenta for the purpose of prevention from intrauterine gro...