期刊论文

Mechanism of Betulinic Acid on Oxidative Stressed Mice Induced by Dexamethasone

中文

动物营养学报

1006-267X

2018

30

3

1035-1043

10.3969/j.issn.1006-267x.2018.03.028

湖南省科技计划项目（2015NK3008）； 湖南省教育厅项目（17A098）； 湖南省自然科学基金项目（2015JJ2077）； 国家级大学生创新创业训练计划项目[（G）SCX1609]；

本校为第一机构

本试验旨在研究桦木酸(BA)对地塞米松(Dex)诱导氧化应激小鼠的保护作用和机制。将40只健康雄性昆明小鼠随机分为5组,即对照(NC)组、Dex组、0.25 mg / kg BA组、 0.50 mg / kg BA组、1.00 mg / kg BA组。NC组和Dex组小鼠灌服1 %的可溶性淀粉溶液,其余各组按不同剂量的BA灌服,连续14 d后,除对照组注射生理盐水外,其余4组均腹腔注射Dex(25 mg / kg BW)诱导氧化应激模型。检测各组小鼠肝脏、脾脏和胸腺总抗氧化能力(T-AOC) 、抑制羟自由基能力和过氧化物酶(POD)的活性,反转录(RT) -PCR检测脾脏和胸腺丝裂原活化蛋白激酶(MAPK)信号通路中凋亡信号调节激酶1(ASK1) 、c-Jun氨基末端激酶(JNK)和P38基因的...

The objective of this research was to evaluate the effects of betulinic acid (BA) on ameliorating dexamethasone (Dex)-induced oxidative damage and the mechanism for the BA-mediated antioxidative effects. Forty male healthy Kunming mice were randomly divided into 5 groups, which were control (NC) group, Dex group, 0.25 mg / kg BA group, 0.50 mg / kg BA group and 1.00 mg / kg BA group. NC and Dex groups were administered orally with 1% starch solution, and the other groups were administered orally with different doses of BA for 14 days. Except NC group, mice in the other groups were intraperiton...