期刊论文

Protective Effects of Betulinic Acid on Immune Organs of Oxidative Damage Mice Induced by Cyclophosphamide

中文

动物营养学报

1006-267X

2018

30

3

1199-1206

10.3969/j.issn.1006-267x.2018.03.047

2015NK3008:湖南省科技计划 17A098:教育厅项目 2015JJ2077:湖南省自然科学基金

本校为第一机构

为了研究桦木酸(BA)对环磷酰胺(Cy)诱导小鼠免疫器官氧化损伤的影响。将50只健康雄性昆明小鼠随机分为5组,即对照组、Cy组及0.05、0.50、5.00 mg / kg BW BA组。对照组和Cy组灌服1%的可溶性淀粉溶液,其余各组按不同剂量的BA灌服,连续14 d后,除对照组注射生理盐水外,其余4组均腹腔注射Cy(50 mg / kg BW)诱导氧化应激模型。收集血清、脾脏和胸腺,检测血清中谷丙转氨酶(ALT) 、谷草转氨酶(AST)活性及白蛋白(ALB) 、总蛋白(TP)含量,检测脾脏和胸腺超氧化物歧化酶(SOD) 、谷胱甘肽过氧化物酶(GSH-Px) 、过氧化氢酶(CAT)活性及还原型谷胱甘肽(GSH) 、丙二醛(MDA)含量。结果显示:1)对于体重,对照组与Cy...

The objective of this research was to evaluate the effects of betulinic acid (BA) on immune organs of oxidative damaged mice induced by cyclophosphamide(Cy). Fifty male healthy Kunming mice were randomly divided into 5 groups, which were control group, Cy group, and 0.05, 0.50 and 5.00 mg / kg BW BA groups. Control and Cy groups were orally administered with 1% starch solution, and the other groups were orally administered with different doses of BA for 14 days. Except control group, mice in the other groups were intraperitoneal injected Cy at the dosage of 50 mg / kg BW to set up oxidative da...