期刊论文

Regulation Mechanism of Plant Polyphenols in Oxidative Stress and Inflammatory Signaling Pathways

中文

动物营养学报

1006-267X

2019

31

4

1554-1563

10.3969/j.issn.1006-267x.2019.04.012

国家自然科学基金应急管理项目(31741115) 动物营养学国家重点实验室开放课题(2004DA125184F1724) 湖南省***计划(2017).

本校为第一机构

炎症及氧化应激是造成动物机体组织和器官损伤的主要原因之一,肠道炎症可造成肠黏膜损伤,进而影响其屏障功能,减弱动物对外界刺激的防御能力。植物多酚具有抗氧化、抗炎、调节肠道菌群等多种潜在功效,且具有低毒、无耐药性等特点,因此,在新型饲料添加剂的开发中具有广阔的应用前景。但目前大部分植物多酚在动物体内的代谢及调控机制尚不明确,这极大阻碍了其合理有效利用。本文基于近期研究就植物多酚对氧化应激与炎症信号通路的调控机制进行综述,为其在新型饲料添加剂中的应用提供理论依据。

Inflammation and oxidative stress are main causes of tissue and organ damage in animals. The intes﹣tinal inflammation may cause damage to intestinal mucosa, and thereby affecting its barrier function and weake﹣ning the animal’s ability to defend against external stimuli. Plant polyphenols are characterized by low toxicity and no drug resistance, and possess multiple potential biological effects such as antioxidant, anti﹣inflammation and intestinal flora regulation. Therefore, polyphenols have a wide application prospect in the development o...