期刊论文

Research Progress of Endoplasmic Reticulum Stress and Intestinal Inflammation Mechanism in Intestinal Epithelial Cells

中文

动物营养学报

1006-267X

2020

32

02

530-539

10.3969/j.issn.1006-267x.2020.02.007

国家自然科学基金青年科学基金项目（31802074）； 湖南省自然科学基金青年基金项目（2019JJ50264）； 农业领域重点研发项目（2017NK2310）；

本校为第一机构

近年来,内质网应激参与动物炎症性肠病发病机制的研究引起了广泛关注,未折叠或错误折叠的蛋白质在内质网腔中过量积累而引发内质网应激,持续的内质网应激则会导致动物肠黏膜屏障损伤并诱发肠道炎症。本文就内质网应激发生机制、未折叠蛋白质反应及内质网应激与肠道炎症互作机制进行了综述,旨在为防治动物肠道炎症提出新的治疗策略。

In recent years, the study of endoplasmic reticulum stress involved in the pathogenesis of inflammatory bowel disease in animals has caused wide attention, unfolded or misfolded proteins accumulate in the lumen of the endoplasmic reticulum and cause endoplasmic reticulum stress, persistent endoplasmic reticulum stress can lead to intestinal mucosal barrier damage and induce intestinal inflammation. This paper reviewed the endoplasmic reticulum stress relieving mechanism, unfolded protein response and interaction mechanism of endoplasmic reticulum stress with intestinal inflammation, aimd to pr...