期刊论文

Yang, LC

英文

TOXINS

2072-6651

2023

15

11

627-

10.3390/toxins15110627

Conceptualization, L.Y.; Methodology, L.Y. and K.W.; Software, S.G.; Validation, S.G.; Formal analysis, K.X. and K.W.; Investigation, K.X. and S.X.; Resources, L.Y.; Data curation, S.G. and C.W.; Writing—original draft preparation, S.G. and M.Z.; Writing—review and editing, L.Y., L.L., L.J., G.Y. and Q.X.; Visualization, K.W.; Supervision, L.Y.; Project administration, L.Y.; Funding acquisition, L.Y. All authors have read and agreed to the published version of the manuscript. This work was supported by the Program of National Natural Science Foundation of China (Grants No. 31802252); Scientific Research Fund of Hunan Provincial Education Department (Grants No. 21A0144); Hunan Provincial Natural Science Foundation of China (Grant No. 2022JJ40182).

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The T-2 toxin (T2) poses a major threat to the health and productivity of animals. The present study aimed to investigate the regulatory mechanism of Nrf2 derived from broilers against T2-induced oxidative damage. DF-1 cells, including those with normal characteristics, as well as those overexpressing or with a knockout of specific components, were exposed to a 24 h treatment of 50 nM T2. The primary objective was to evaluate the indicators associated with oxidative stress and the expression of downstream antioxidant factors regulated by the Nrf2-ARE signaling pathway, at both the mRNA and pro...