PLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration

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成果类型：

期刊论文

作者：

Chang, Wen-Lin;Liu, Ya-Wei;Dang, Yan-Li;Jiang, Xiang-Xiang;Xu, Honglin;...

通讯作者：

Wang, Hongmei;Meng, Wenxiang

作者机构：

[Wang, Hongmei; Lin, Hai-Yan; Zhu, Cheng; Jiang, Xiang-Xiang; Chang, Wen-Lin; Liu, Ya-Wei; Wang, Haibin; Wang, Yan-Ling; Huang, Xing] Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China.

[Chang, Wen-Lin] Hong Kong Univ Sci & Technol, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen Peking Univ,Med Ctr, Inst Urol,Peking Univ,Shenzhen Hosp,Biomed Res In, Shenzhen 518036, Peoples R China.

[Xue, Li-Qun; Chang, Wen-Lin] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Jiang, Xiang-Xiang; Liu, Ya-Wei] Univ Chinese Acad Sci, Beijing 100039, Peoples R China.

[Dang, Yan-Li] PLA, Hosp 306, Dept Obstet & Gynecol, Beijing 100101, Peoples R China.

通讯机构：

[Wang, Hongmei; Meng, Wenxiang] C

Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China.

Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100190, Peoples R China.

语种：

英文

关键词：

PLAC8;Extravillous trophoblast cells;Marker;Invasion and migration;Placenta;Preeclampsia

期刊：

DEVELOPMENT

ISSN：

0950-1991

年：

2018

卷：

145

期：

页码：

dev148932

DOI：

10.1242/dev.148932

基金类别：

This study was supported by grants from the National Natural Science Foundation of China (31701305 and 81490741) and the Ministry of Science and Technology of the People’s Republic of China (2016YFC1000208 and 2017YFC1001401). Deposited in PMC for immediate release.

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本校为其他机构

院系归属：

动物医学院

摘要：

Proper differentiation of trophoblast cells in the human placenta is a prerequisite for a successful pregnancy, and dysregulation of this process may lead to malignant pregnancy outcomes, such as preeclampsia. Finding specific markers for different types of trophoblast cells is essential for understanding trophoblast differentiation. Here, we report that placenta-specific protein 8 (PLAC8) is specifically expressed in the interstitial extravillous trophoblast cells (iEVTs) on the fetomaternal interface. Using model systems, including placental villi-decidua co-culture, iEVTs induction by using...

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PLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration

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