A fast approach to detect gene-gene synergy

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成果类型：

期刊论文

作者：

Xing, Pengwei;Chen, Yuan;Gao, Jun;Bai, Lianyang*;Yuan, Zheming*

通讯作者：

Yuan, Zheming;Bai, Lianyang

作者机构：

[Xing, Pengwei; Chen, Yuan; Yuan, Zheming] Hunan Agr Univ, Hunan Engn & Technol Res Ctr Agr Big Data Anal De, Changsha 410128, Hunan, Peoples R China.

[Xing, Pengwei; Chen, Yuan; Yuan, Zheming] Hunan Agr Univ, Hunan Prov Key Lab Biol & Control Plant Dis & Ins, Changsha 410128, Hunan, Peoples R China.

[Gao, Jun] Univ Arkansas Med Sci, Dept Biochem & Mol Biol, Little Rock, AR 72205 USA.

[Bai, Lianyang] Hunan Acad Agr Sci, Biotechnol Res Ctr, Changsha 410125, Hunan, Peoples R China.

通讯机构：

[Yuan, Zheming; Bai, Lianyang] H

Hunan Agr Univ, Hunan Engn & Technol Res Ctr Agr Big Data Anal De, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Hunan Prov Key Lab Biol & Control Plant Dis & Ins, Changsha 410128, Hunan, Peoples R China.

Hunan Acad Agr Sci, Biotechnol Res Ctr, Changsha 410125, Hunan, Peoples R China.

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2017

卷：

期：

页码：

16437

DOI：

10.1038/s41598-017-16748-w

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61701177]; Hunan Provincial Department of Education [1071]

机构署名：

本校为第一且通讯机构

院系归属：

植物保护学院

摘要：

AbstractSelecting informative genes, including individually discriminant genes and synergic genes, from expression data has been useful for medical diagnosis and prognosis. Detecting synergic genes is more difficult than selecting individually discriminant genes. Several efforts have recently been made to detect gene-gene synergies, such as dendrogram-based I(X1; X2; Y) (mutual information), doublets (gene pairs) and MIC(X1; X2; Y) based on the maximal information coefficient. It is unclear whether dendrogram-based I(X1; X2; Y) and doublets can...

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A fast approach to detect gene-gene synergy

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