Screening of probiotic Lactobacilli with potential anti-allergic activity based on hyaluronidase inhibition and degranulation of RBL-2H3 cells in vitro

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成果类型：

期刊论文

作者：

Lei, Wenping;Liu, Chengguo;Pan, Lina;Peng, Can;Wang, Jiaqi;...

通讯作者：

Jiaqi Wang<&wdkj&>Hui Zhou

作者机构：

[Liu, Chengguo; Lei, Wenping; Zhou, Hui] Hunan Agr Univ, Coll Food Sci & Technol, 1 Nongda Rd, Changsha 410125, Hunan, Peoples R China.

[Peng, Can; Wang, Jiaqi; Pan, Lina] Ausnutria Dairy China Co Ltd, 168 Huangxing Middle Rd, Changsha 410125, Hunan, Peoples R China.

通讯机构：

[Jiaqi Wang] A

[Hui Zhou] C

Ausnutria Dairy (China) Co., Ltd., Changsha, Hunan, China<&wdkj&>College of Food Science and Technology, Hunan Agricultural University, Changsha, Hunan, China

语种：

英文

关键词：

Cell membranes;Cytology;Diagnosis;Diseases;Lactic acid;Allergic disease;Anti-allergic activities;Immunoblot analysis;Inflammatory disease;Inhibition assays;Lactic acid bacteria;Probiotic lactobacilli;Probiotic potentials;Probiotics

期刊：

LWT

ISSN：

0023-6438

年：

2021

卷：

140

页码：

110707

DOI：

10.1016/j.lwt.2020.110707

基金类别：

This work was supported by Project of Science and Technology Department of Hunan Province, China [grant numbers 2017GK4032 ], National Natural Science Foundation of China [grant numbers 31571811 ], and Ausnutria Dairy (China) Co., Ltd . This work was supported by Project of Science and Technology Department of Hunan Province, China [grant numbers 2017GK4032], National Natural Science Foundation of China [grant numbers 31571811], and Ausnutria Dairy (China) Co. Ltd.

机构署名：

本校为第一机构

院系归属：

食品科学技术学院

摘要：

In the present study, the probiotic potential of lactic acid bacteria (LAB) isolated from different dairy sources were evaluated, and probiotics with anti-allergic activity were further screened based on the hyaluronidase inhibition assay and the degranulation of RBL-2H3 cells in vitro. As a result, Out of 20 strains, 15 LAB exhibited desirable probiotic properties and safety in vitro. Considering the suppressive activities on hyaluronidase and β-hexosaminidase release in degranulation-induced RBL-2H3 cells, strains LZ077E, LZ183E, and LZ260E ...

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Screening of probiotic Lactobacilli with potential anti-allergic activity based on hyaluronidase inhibition and degranulation of RBL-2H3 cells in vitro

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