l‐Theanine delays d‐galactose‐induced senescence by regulating the cell cycle and inhibiting apoptosis in rat intestinal cells

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成果类型：

期刊论文

作者：

Xu, Wei;Xiang, Xi;Lin, Ling;Gong, Zhi-Hua*;Xiao, Wen-Jun

通讯作者：

Gong, Zhi-Hua;Xiao, WJ

作者机构：

[Gong, Zhi-Hua; Xiao, Wen-Jun; Xiao, WJ; Xu, Wei; Xiang, Xi; Lin, Ling; Gong, ZH] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha, Peoples R China.

[Gong, Zhi-Hua; Xiao, Wen-Jun; Xu, Wei; Xiang, Xi; Lin, Ling] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingre, Changsha, Peoples R China.

[Gong, Zhi-Hua; Xiao, Wen-Jun; Xu, Wei; Xiang, Xi; Lin, Ling] Hunan Agr Univ, Sino Kenya Joint Lab Tea Sci, Changsha, Peoples R China.

通讯机构：

[Xiao, WJ ; Gong, ZH] H

Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha, Peoples R China.

语种：

英文

关键词：

l-theanine;IEC-6 cell;apoptosis;cell cycle;oxidative stress;senescence

期刊：

Journal of the Science of Food and Agriculture

ISSN：

0022-5142

年：

2024

卷：

104

期：

页码：

2073-2084

DOI：

10.1002/jsfa.13096

基金类别：

This work was supported by the National Key Research and Development Program of China (No. 2022YFD1600805), and the Major Science and Technology Project of Hunan Province (No. 2021NK1020).

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

AbstractBACKGROUNDIntestinal senescence is associated with several aging‐related diseases. l‐Theanine (LTA) has demonstrated strong potential as an antioxidant and antisenescence agent. This study investigated the regulatory effect of LTA on cellular senescence using an in vitro model of d‐galactose (D‐Gal)‐induced senescence in the rat epithelial cell line, intestinal epithelioid cell‐6 (IEC‐6).RESULTSTreatment of IEC‐6 cells with 40 mg/mL D‐Gal for 48 h resulted in the successful development of the senescent cell model. Compared wi...

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l‐Theanine delays d‐galactose‐induced senescence by regulating the cell cycle and inhibiting apoptosis in rat intestinal cells

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