Antimicrobial Triclocarban Exhibits Higher Agonistic Activity on Estrogen-Related Receptor gamma than Triclosan at Human Exposure Levels: A Novel Estrogenic Disruption Mechanism
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21906050, 21806035, 21806003, 21777187]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [2019JJ50226]
机构署名：
本校为第一且通讯机构
院系归属：
资源环境学院
摘要：
Triclosan (TCS) and triclocarban (TCC) are two widely used antimicrobial agents that have been reported to be estrogenic disruptors. Previous researches have shown that TCC and TCS exhibit weak or no agonistic activity on classical estrogen receptors. We demonstrate first in the present study that TCS and TCC disrupt the estrogen system via the estrogen-related receptor γ(ERRÎ) at human exposure levels. The fluorescence competitive binding assay showed that TCC had approximately 9-fold higher binding affinity with ERRγthan TCS. TCS and TCC d...
