Fluoride induced leaky gut and bloom of Erysipelatoclostridium ramosum mediate the exacerbation of obesity in high-fat-diet fed mice

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成果类型：

期刊论文

作者：

Chen, Guijie;Peng, Yujia;Huang, Yujie;Xie, Minhao;Dai, Zhuqing;...

通讯作者：

Zeng, XX;Liu, ZH

作者机构：

[Chen, Guijie; Chen, Dan; Xie, Zhiyong; Huang, Yujie; Xu, Weiqi; Chen, Chunxu; Fan, Xia; Peng, Yujia; Zeng, Xiaoxiong; Kan, Xuhui; Sun, Yi; Dong, Wei; Zhou, Wangting; Yang, Tingting] Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China.

[Xie, Minhao] Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Collaborat Innovat Ctr Modern Grain Circulat & Saf, Nanjing 210023, Peoples R China.

[Dai, Zhuqing] Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Peoples R China.

[Cai, Huimei] Anhui Agr Univ, Sch Tea & Food Sci & Technol, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Anhui, Peoples R China.

[Liu, Zhonghua] Hunan Agr Univ, Key Lab Minist Educ Tea Sci, Changsha 410128, Peoples R China.

通讯机构：

[Zeng, XX ] N

[Liu, ZH ] H

Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China.

Hunan Agr Univ, Key Lab Minist Educ Tea Sci, Changsha 410128, Peoples R China.

语种：

英文

关键词：

Fluoride;Exacerbation of obesity;Intestinal barrier permeability;Gut microbiota;Erysipelatoclostridium ramosum

期刊：

Journal of Advanced Research

ISSN：

2090-1232

年：

2023

卷：

页码：

35-54

DOI：

10.1016/j.jare.2022.10.010

基金类别：

Key Technology Ramp;D Program of Jiangsu Province [BE2020341]; National Key Research and Development Program of China [2018YFC1604404]; Fundamental Research Funds for the Central Universities [KJQN202154]; Priority Academic Program Development of Jiangsu Higher Education Institutions

机构署名：

本校为通讯机构

院系归属：

园艺园林学院

摘要：

Introduction: Fluoride is widely presented in drinking water and foods. A strong relation between fluoride exposure and obesity has been reported. However, the potential mechanisms on fluoride-induced obesity remain unexplored. Objectives and methods The effects of fluoride on the obesity were investigated using mice model. Furthermore, the role of gut homeostasis in exacerbation of the obesity induced by fluoride was evaluated. Results The results showed that fluoride alone did not induce obesity in normal diet (ND) fed mice, whereas, it could trigger exacerbation of obesity in high-fat diet ...

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Fluoride induced leaky gut and bloom of Erysipelatoclostridium ramosum mediate the exacerbation of obesity in high-fat-diet fed mice

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