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Dipylidium caninum draft genome - a new resource for comparative genomic and genetic explorations of flatworms

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成果类型：

期刊论文

作者：

Liu, Guo-Hua*;Korhonen, Pasi K.;Young, Neil D.;Lu, Jiang;Wang, Tao;...

通讯作者：

Liu, Guo-Hua;Gasser, Robin B;Zhu, Xing-Quan

作者机构：

[Liu, Guo-Hua; Zhu, Xing-Quan; Wang, Shuai] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Vet Parasitol Gansu Prov, State Key Lab Vet Etiol Biol, Lanzhou 730046, Peoples R China.

[Fu, Yi-Tian; Liu, Guo-Hua] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

[Korhonen, Pasi K.; Gasser, Robin B.; Hofmann, Andreas; Young, Neil D.; Wang, Tao; Koehler, Anson V.; Chang, Bill C. H.] Univ Melbourne, Fac Vet & Agr Sci, Melbourne Vet Sch, Dept Vet Biosci, Parkville, Vic 3010, Australia.

[Zhang, Hui; Li, Nan; Xiangli, Lingzi; Liu, Wei-Min; Li, Hua-Wei; Lin, Lin; Lu, Jiang; Lin, Chu-Yu] Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen 518124, Peoples R China.

[Zhang, Hui; Li, Nan; Xiangli, Lingzi; Liu, Wei-Min; Li, Hua-Wei; Lin, Lin; Lu, Jiang; Lin, Chu-Yu] Shenzhen Zhong Nong Jing Yue Biotech Co Ltd, Shenzhen 518124, Peoples R China.

通讯机构：

[Zhu, Xing-Quan; Liu, Guo-Hua] C

[Gasser, Robin B] D

College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China. Electronic address:

Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville 3010, Australia. Electronic address:

College of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, China. Electronic address:

语种：

英文

关键词：

Cestode;Tapeworm;Dipylidium caninum;Nuclear genome;Comparative genomic and genetic analyses

期刊：

Genomics

ISSN：

0888-7543

年：

2021

卷：

113

期：

页码：

1272-1280

DOI：

10.1016/j.ygeno.2021.02.019

基金类别：

This project was funded by the International Science & Technology Cooperation Program of China (grant no. 2013DFA31840), the Training Program for Excellent Young Innovators of Changsha (grant no. KH2002001), the Planned Program of Hunan Province Science and Technology Innovation (grant no. 2018RS3085) and the Agricultural Science and Technology Innovation Program (ASTIP) of China (grant no. CAAS-ASTIP-2016-LVRI-03). Support from the Australian Research Council (ARC), the National Health and Medical Research Council of Australia (NHMRC) and The University of Melbourne (RBG) is gratefully acknowledged. NDY and PKK held NHMRC Career Development and Early Career Research Fellowships, respectively.

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院系归属：

动物医学院

摘要：

Here, we present a draft genome of the tapeworm Dipylidium caninum (family Dipylidiidae) and compare it with other cestode genomes. This draft genome of D. caninum is 110 Mb in size, has a repeat content of ~13.4% and is predicted to encode ~10,000 protein-coding genes. We inferred excretory/secretory molecules (representing the secretome), other key groups of proteins (including peptidases, kinases, phosphatases, GTPases, receptors, transporters and ion-channels) and predicted potential intervention targets for future evaluation. Using 144 sha...

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Dipylidium caninum draft genome - a new resource for comparative genomic and genetic explorations of flatworms

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