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The Protective Effects of L-Theanine against Epigallocatechin Gallate-Induced Acute Liver Injury in Mice

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成果类型:
期刊论文
作者:
Zhu, Kun;Zeng, Hongzhe;Yue, Lin;Huang, Jianan;Ouyang, Jie;...
通讯作者:
Liu, ZH;Ouyang, J
作者机构:
[Zhu, Kun] Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Peoples R China.
[Yue, Lin; Zeng, Hongzhe; Liu, Zhonghua; Huang, Jianan; Zhu, Kun] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Peoples R China.
[Ouyang, Jie; Ouyang, J] Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Changsha 410125, Peoples R China.
通讯机构:
[Ouyang, J ; Liu, ZH ] H
Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Peoples R China.
Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Changsha 410125, Peoples R China.
语种:
英文
关键词:
L-theanine;EGCG;liver injury;oxidative stress;metabolomics
期刊:
Foods
ISSN:
2304-8158
年:
2024
卷:
13
期:
7
页码:
1121-
基金类别:
Conceptualization, J.O. and Z.L.; Data Curation, K.Z. and J.O.; Formal Analysis, K.Z.; Funding Acquisition, J.O. and Z.L.; Investigation, K.Z., H.Z., L.Y. and J.O.; Methodology, K.Z., H.Z., L.Y. and J.O.; Project Administration, J.H. and Z.L.; Software, K.Z.; Visualization, K.Z.; Writing—Original Draft, K.Z. and J.O.; Writing—Review and Editing, K.Z., J.H. and Z.L. All authors have read and agreed to the published version of the manuscript. This research was supported by the Agricultural Science and Technology Innovation Program of Hunan Province (2023CX113), China Agriculture Research System of MOF and MARA (CARS-23), Key Research and Development Program of Hunan Province of China (2020NK2030, 2020WK2017), and the Major Project of Science and Technology of Guangxi Province of China (AA20302018-17).
机构署名:
本校为通讯机构
院系归属:
园艺园林学院
摘要:
Epigallocatechin-3-gallate (EGCG) is a main bioactive constituent in green tea. Being a redox-active polyphenol, high-dose EGCG exhibits pro-oxidative activity and could cause liver injury. L-theanine is a unique non-protein amino acid in green tea and could provide liver-protective effects. The purpose of this study was to investigate the hepatoprotective effects of L-theanine on EGCG-induced liver injury and the underlying mechanisms. A total of 300 mg/kg L-theanine was administrated to ICR mice for 7 days. Then, the acute liver injury model was established through intragastric administratio...

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