期刊论文

中文

畜牧兽医学报

0366-6964

2018

49

4

818-824

10.11843/j.issn.0366-6964.2018.04.020

湖南省科技计划项目（2015NK3008） 湖南省教育厅项目（17A098） 湖南省自然科学基金（2015JJ2077）

本校为第一机构

旨在研究桦木酸(betulinic acid,BA)对环磷酰胺(cyclophosphamide,Cy)致小鼠肠道氧化损伤的影响。将健康雄性昆明小鼠随机分为5组:对照(NC)组、Cy组、0.5mg·kg~(-1) BA组、5.0mg·kg~(-1) BA组、50.0mg·kg~(-1) BA组。NC组和Cy组灌服1%的可溶性淀粉,其余各组按不同剂量的BA混悬于可溶性淀粉中灌服,1次·d~(-1),连续14d后,除NC组注射生理盐水外,其余4组均连续2d腹腔注射Cy(50mg·kg~(-1))诱导肠氧化损伤模型。检测肝、脾和胸腺指数,肠黏膜中分泌型免疫球蛋白α(secretory immunoglobulin a,SIgA)水平,血清和肠道中超氧化物歧化酶(superoxide dismutase,SOD)活性,还原型谷胱甘肽(glutathione,GS...

The experiment was conducted to evaluate the effect of betulinic acid (BA) on intestinal oxidative damage induced by cyclophosphamide (Cy) in mice.Male Kunming mice were randomly divided into 5 groups:control group (NC),Cy group,0.5 mg · kg-1 BA group,5.0 mg · kg-1 BA group and 50.0 mg · kg-1 BA group.The control and Cy group were administered orally with 1％ starch and the other groups were administered orally with different doses of BA (0.5,5.0,and 50.0 mg · kg-1) daily for 14 days.The model of intestinal oxidative damage was set up in mi...