期刊论文

Research Progresses on the Formation and Development of Primordial Follicles in Mammals

中文

畜牧兽医学报

0366-6964

2020

51

3

417-425

10.11843/j.issn.0366-6964.2020.03.002

国家自然科学基金（31672507）；

本校为第一机构

在大多数雌性哺乳动物中,早期原始卵泡的形成主要包括3个过程:原始生殖细胞的迁移、生殖细胞减数分裂和生殖细胞巢破裂。原始卵泡形成与发育过程涉及到诸多因子和信号通路的调节作用,且原始卵泡库的大小及储备能力将决定雌性动物终生生殖能力。本文就参与原始卵泡形成和发育过程中的因子和信号通路作一综述,旨在深入了解参与原始卵泡形成与发育的细胞和分子机制,为维持原始卵泡库及促进原始卵泡激活提供研究思路。

In most female mammals, the migration of primordial germ cells, germ cells meiosis, and breakdown of germ cell nests are regarded as the 3 critical processes for the formation of early primordial follicles. In addition, there are some special factors and signaling pathways regulating the formation and development of primordial follicles. However, the reproductive ability of a female is determined by the size and reserve capacity of her primordial follicle pool. This review summarizes the factors and signaling pathways involved in the formation and development of primordial follicles, with the ...