Two O-methyltransferases are responsible for multiple O-methylation steps in the biosynthesis of furanocoumarins from Angelica decursiva

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成果类型：

期刊论文

作者：

He, Yuedong;Zhang, Jing;He, Yuewei;Liu, Huhu;Wang, Chong;...

通讯作者：

Tian, Yun;Lu, XY;Zhong, XH

作者机构：

[Tian, Yun; Tian, Y; Liu, Huhu; Lu, Xiangyang; Wang, Chong; He, Yuedong; Guan, Guiping; Lu, XY] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

[Zhong, Xiaohong; Zhang, Jing] Hunan Agr Univ, Coll Hort, Changsha 410128, Hunan, Peoples R China.

[He, Yuewei] Hunan Agr Univ, Coll Environm & Ecol, Changsha 410128, Hunan, Peoples R China.

[Zhao, Yucheng] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 210009, Jiangsu, Peoples R China.

通讯机构：

[Tian, Y; Lu, XY ; Zhong, XH ] H

Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Coll Hort, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Coumarins;Biosynthesis;O-Methyltransferase;Catalytic promiscuity and fidelity;Angelica decursiva

期刊：

Plant Physiology and Biochemistry

ISSN：

0981-9428

年：

2023

卷：

204

页码：

108142

DOI：

10.1016/j.plaphy.2023.108142

基金类别：

This work was supported by the National Key R&D Program of China (No. 2019YFC1604903), the Science and Technology Innovation Program of Hunan Province (No. 2022RC1170) and the Training Program for Excellent Young Innovators of Changsha (No. kq2206037).

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

生物科学技术学院

摘要：

Angelica decursiva, an important traditional medicinal plant, possesses a unique pharmacological activity. Its principal active ingredients are coumarins, including scopoletin, bergapten, and imperatorin. However, the enzymes catalyzing the critical step of coumarins biosynthesis pathway remain unidentified. This study initially screened 14 candidate O-methyltransferases (OMTs) through transcriptomics and metabolic determination. Combined with gene expression profile and biochemical assays, two OMTs (AdOMT1 and AdOMT2) were identified to be responsible for the O-methylation of coumarins in A. ...

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Two O-methyltransferases are responsible for multiple O-methylation steps in the biosynthesis of furanocoumarins from Angelica decursiva

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