期刊论文

Changes of Three Endogenous Gas Molecules in the Blood of Plateau Pika Exposed to Hypoxia

中文

基因组学与应用生物学

1674-568X

2021

40

4

1539-1543

10.13417/j.gab.040.001539

国家自然科学基金项目（31760117）； 青海省科技厅自然科学基金项目（2019-ZJ-924）共同资助；

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内源性NO和CO以及H_2S是目前发现的三种气体信号分子,在血管收缩调节和血管重构反应中发挥重要作用,影响肺血管收缩反应(HPV)。本实验模拟5 000 m海拔高度,对高原鼠兔(Ochotona curzoniae)和SD大鼠进行不同时间的低氧处理,分别测定平均肺动脉压、右心指数和血液中内源性NO和CO以及H_2S的浓度,以揭示三种气体分子在高原鼠兔低氧适应中的作用。研究结果显示:(1)随着低氧时间的增加,高原鼠兔肺动脉压没有出现显著性差异(P>0.05),右心指数并未出现显著性变化(P>0.05);SD大鼠肺动脉压在低氧7 d时出现极显著性增加(P0.05),低氧7 d和21 d H_2S浓度出现极显著性增加(P

Endogenous NO, CO and H_2S are the three gas signal molecules currently discovered, which play an important role in vasoconstriction regulation and vascular remodeling reactions, affecting hypoxic pulmonary vasoconstriction(HPV). In this experiment, the altitude of 5 000 m was simulated, and the plateau pika(Ochotona curzoniae)and the SD rat were treated with hypoxia at different times, to measure the mean pulmonary artery pressure, right heart index, and the concentration of endogenous NO, CO, and H_2S in the blood to reveal the role of three gas molecules in hypoxic adaptation of plateau pik...