Peroxisome proliferator-activated receptor (PPAR) gamma has been reported to be implicated in placentation in mice. Previous studies have demonstrated that PPARgamma is also expressed in porcine placenta, primarily localized in vascular endothelial cells (VECs). The present study aimed to investigate the roles of PPARgamma during porcine placental angiogenesis and examine the molecular mechanisms involved in its actions. VECs were incubated with the PPARgamma agonist rosiglitazone and the antagonist T0070907, and their angiogenic potential was evaluated using cellular impedance, wound healing ...
