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Peroxisome proliferator-activated receptor γ mediates porcine placental angiogenesis through hypoxia inducible factor-, vascular endothelial growth factor- and angiopoietin-mediated signaling

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成果类型:
期刊论文
作者:
Zhang, Juzuo;Peng, Xuan;Yuan, Anwen;Xie, Yang;Yang, Qing*;...
通讯作者:
Yang, Qing;Xue, Liqun
作者机构:
[Xie, Yang; Zhang, Juzuo; Yuan, Anwen; Yang, Qing; Xue, LQ; Peng, Xuan; Xue, Liqun] Hunan Agr Univ, Coll Vet Med, Dept Clin Vet Med, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.
通讯机构:
[Yang, Q; Xue, LQ] H
Hunan Agr Univ, Coll Vet Med, Dept Clin Vet Med, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.
语种:
英文
关键词:
2 chloro 5 nitro n (4 pyridyl)benzamide;angiopoietin;angiopoietin 1;angiopoietin 2;CD31 antigen;hypoxia inducible factor;hypoxia inducible factor 1alpha;hypoxia inducible factor 2alpha;messenger RNA;peroxisome proliferator activated receptor gamma;placental growth factor;rosiglitazone;unclassified drug;vasculotropin;vasculotropin 120;vasculotropin 164;vasculotropin 188;vasculotropin receptor;vasculotropin receptor 1;vasculotropin receptor 2;von Willebrand factor;angiopoietin;basic helix loop helix transcription factor;endothelial PAS domain-containing protein 1;hypoxia inducible factor 1;peroxisome proliferator activated receptor gamma;vasculotropin;angiogenesis;animal experiment;animal tissue;Article;cell migration;cell proliferation;controlled study;down regulation;enzyme activation;impedance;Landrace pig;nonhuman;placenta;protein expression;reverse transcription polymerase chain reaction;signal transduction;upregulation;Western blotting;wound healing assay;angiogenesis;animal;cell adhesion;cell culture;cytology;endothelium cell;female;metabolism;physiology;pig;placenta;pregnancy;signal transduction;vascularization;Angiopoietins;Animals;Basic Helix-Loop-Helix Transcription Factors;Cell Adhesion;Cell Proliferation;Cells, Cultured;Endothelial Cells;Female;Hypoxia-Inducible Factor 1;Neovascularization, Physiologic;Placenta;PPAR gamma;Pregnancy;Signal Transduction;Swine;Vascular Endothelial Growth Factors
期刊:
MOLECULAR MEDICINE REPORTS
ISSN:
1791-2997
年:
2017
卷:
16
期:
3
页码:
2636-2644
基金类别:
Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31172377, 31272630, 31572591]; Key Projects of Hunan Province Education Office [14A069]
机构署名:
本校为第一且通讯机构
院系归属:
动物医学院
摘要:
Peroxisome proliferator-activated receptor (PPAR) γ has been reported to be implicated in placentation in mice. Previous studies have demonstrated that PPARγ is also expressed in porcine placenta, primarily localized in vascular endothelial cells (VECs). The present study aimed to investigate the roles of PPARγ during porcine placental angiogenesis and examine the molecular mechanisms involved in its actions. VECs were incubated with the PPARγ agonist rosiglitazone and the antagonist T0070907, and their angiogenic potential was evaluated us...

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