期刊论文

Yi, Jin-E;Obminska-Mrukowicz, Bozena

英文

IN VIVO

0258-851X

2018

32

5

1081-1088

10.21873/invivo.11349

The Authors wish to thank B.C. Ruetgen (Institute of Immunology, Department of Pathobiology, University of Veterinary Medicine in Vienna) for providing CLBL-1 cell line, and Y. Fujino and H. Tsujimoto (University of Tokyo, Department of Veterinary Internal Medicine) for providing the CL-1 cell line. The Authors are grateful for the financial support from the National Key Research and Development Program of China (No. 2016YFD0501209) and Department of Education of Hunan Province, China (Key project No.17A098). Publication was supported by Wrocław Centre of Biotechnology, programme: the Leading National Research Centre (KNOW) for years 2014-2018.

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Background/Aim: Betulinic acid (BA) and betulin (BT) exhibit a variety of pharmacological properties including anti-cancer, anti-inflammatory and anti-oxidant ones. Canine lymphoma and osteosarcoma have a high mortality rate and need more effective therapeutic approaches. In this study, the anti-proliferative and pro-apoptotic effects of BA and BT were investigated in canine T-cell lymphoma (CL-1), canine B-cell lymphoma (CLBL-1) and canine osteosarcoma (D-17) cell lines. Materials and Methods: The cultured cells were treated with several conce...