版权说明 操作指南
首页 > 成果 > 详情

CRISPR-activation screen identified potassium channels for protection against mycotoxins through cell cycle progression and mitochondrial function.

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Tang, Yulong;Liao, Simeng;Nie, Zhuyuan;Kuang, Guangwei;Ji, Chunxiao;...
作者机构:
[Liao, Simeng; Wan, Dan; Wu, Xin; Li, Fengna; Yin, Yulong; Nie, Zhuyuan; Kong, Xiangfeng; Tang, Yulong; He, Liuqin] Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China
[Zhan, Kai; Tang, Yulong] Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Hefei, 230001, China
[Tan, Bie; Ji, Chunxiao; Yin, Yulong; Nie, Zhuyuan] College of Animal Science and Technology, Hunan Agricultural University, Changsha, China
[Kuang, Guangwei] Hunan Provincial Institute of Animal Drug and Feed Supervision, Changsha, 410006, China
语种:
英文
关键词:
CRISPR-Cas9 screening;cell cycle;mitochondria;potassium channels;zearalenone
期刊:
Cell Stress
ISSN:
2523-0204
年:
2023
卷:
7
期:
5
页码:
34-45
机构署名:
本校为其他机构
院系归属:
动物科学技术学院
摘要:
Zearalenone (ZEA) exposure has carcinogenic effects on human and animal health by exhibiting intestinal, hepatic, and renal toxicity. At present, the underlying mechanisms on how ZEA induces apoptosis and damage to tissues still remain unclear. In this study, we aimed to identify genes that modulate the cellular response to ZEA using clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 screening, and further validate novel gene functions to elucidate molecular mechanisms underlying particular biological processes in vivo and in vitro. Two ZEA-resistant cell lines, designated...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com