Dynamic RNA profiles in the small intestinal epithelia of cats after Toxoplasma gondii infection

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成果类型：

期刊论文

作者：

Zhai, Bintao;Xie, Shi-Chen;Zhang, Jiyu;He, Jun-Jun*;Zhu, Xing-Quan

通讯作者：

Zhu, XQ;He, Jun-Jun

作者机构：

[Zhang, Jiyu; Zhai, Bintao] Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Key Lab Vet Pharmaceut Dev, Minist Agr & Rural Affairs, Lanzhou 730050, Gansu, Peoples R China.

[Zhai, Bintao] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Anim Dis Control & Prevent, Key Lab Vet Parasitol Gansu Prov, Lanzhou 730046, Gansu, Peoples R China.

[Xie, Shi-Chen; Zhu, Xing-Quan] Shanxi Agr Univ, Coll Vet Med, Lab Parasit Dis, Taigu 030801, Shanxi, Peoples R China.

[Xie, Shi-Chen] Hunan Agr Univ, Coll Vet Med, Res Ctr Parasites & Vectors, Changsha 410128, Hunan, Peoples R China.

[He, Jun-Jun; Zhu, Xing-Quan] Yunnan Agr Univ, Coll Vet Med, Key Lab Vet Publ Hlth Yunnan Prov, Kunming 650201, Yunnan, Peoples R China.

通讯机构：

[He, JJ; Zhu, XQ ]

Shanxi Agr Univ, Coll Vet Med, Lab Parasit Dis, Taigu 030801, Shanxi, Peoples R China.

Yunnan Agr Univ, Coll Vet Med, Key Lab Vet Publ Hlth Yunnan Prov, Kunming 650201, Yunnan, Peoples R China.

语种：

英文

关键词：

Toxoplasma gondii;Definitive host;Cat;Small intestinal epithelia;Long non-coding RNA;Circular RNA;mRNA

期刊：

贫困所致传染病(英文)

ISSN：

2095-5162

年：

2023

卷：

期：

页码：

1-20

DOI：

10.1186/s40249-023-01121-z

基金类别：

Project support was kindly provided by the National Key Research and Development Program of China (Grant Nos. 2021YFC2300800 and 2021YFC2300802), the National Natural Science Foundation of China (Grant Nos. 32172887 and 32102701), the Youth Science and Technology Fund Program of Gansu province (Grant No. 23JRRA562), the Innovation Project of Chinese Academy of Agricultural Sciences (Grant No. 25-LZIHPS-05), the Agricultural Science and Technology Innovation Program (ASTIP) (Grant No. CAAS-ASTIP-2016-LVRI-03) and the Yunnan Expert Workstation (Grant No. 202005AF150041). The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

Background:Felids are the only definitive hosts of Toxoplasma gondii. However, the biological features of the feline small intestine following T. gondii infection are poorly understood. We investigated the changes in the expression of RNAs (including mRNAs, long non-coding RNAs and circular RNAs) in the small intestinal epithelia of cats following T. gondii infection to improve our understanding of the life cycle of T. gondii and cat responses to T. gondii infection. Methods:Fifteen cats were randomly assigned to five groups, and the infection groups were inoculated with 600 tissue ...

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Dynamic RNA profiles in the small intestinal epithelia of cats after Toxoplasma gondii infection

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