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Helicase-independent function of RIG-I against murine gammaherpesvirus 68 via blocking the nuclear translocation of viral proteins

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成果类型:
期刊论文
作者:
Xu, Yang;Hou, Guoli;Liu, Qizhi;Zhang, Qiushi;Li, Chun;...
通讯作者:
Li, Deliang;Li, JH
作者机构:
[Li, Junhua; Hu, Liang; Chen, Rui; Xu, Yang; Li, Chun; Chen, Xiaoying; Li, Deliang; Hou, Guoli; Zhang, Qiushi] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.
[Liu, Qizhi] Cedars Sinai Med Ctr, Samuel Oschin Canc Inst, Dept Surg, Los Angeles, CA 90048 USA.
[Ding, Chengming] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Li, JH ; Li, DL] H
Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.
语种:
英文
关键词:
Gamma herpesviruses 68;Helicase-independent;Nuclear translocation;RIG-I;RTA
期刊:
International Journal of Biological Macromolecules
ISSN:
0141-8130
年:
2023
卷:
250
页码:
126527
基金类别:
CRediT authorship contribution statement J.H. Li conceived the ideas and designed the experiments. Y. Xu, G.L. Hou, Q.Z. Liu, Q.S. Zhang, C. Li, L. Hu, X.Y. Chen, and R. Chen performed the majority of experiments. C.M. Ding and D.L. Li are responsible for resources. J.H. Li and D.L. Li are responsible for funding acquisition. Y. Xu and G.L. Hou write the original draft. J.H. Li supervised the study. All authors discussed the results and commented on the manuscript.
机构署名:
本校为第一且通讯机构
院系归属:
动物科学技术学院
摘要:
Innate immunity is the first line of defense against viral pathogens. Retinoic Acid-Inducible Gene 1 (RIG-I) is a pattern recognition receptor that recognizes virus-associated double-stranded RNA and initiates the interferon responses. Besides signal transduction, RIG-I exerts direct antiviral functions to displace viral proteins on dsRNA via its Helicase activity. Nevertheless, this effector-like activity of RIG-I against herpesviruses remains largely unexplored. It has been previously reported that herpesviruses deamidate RIG-I, resulting in ...

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