Various novel colistin resistance mechanisms interact to facilitate adaptation of aeromonas hydrophila to complex colistin environments

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成果类型：

期刊论文

作者：

Liu, Junqi;Xiao, Gang;Zhou, Wangping;Yang, Jun;Wang, Yang;...

通讯作者：

Sun, Zhiliang

作者机构：

[Liu, Junqi; Wu, Yong; Cheng, Xiaojun; Xiao, Gang; Sun, Zhiliang] Hunan Agr Univ, Coll Vet Med, Changsha, Hunan, Peoples R China.

[Liu, Junqi; Yang, Jun; Zhou, Wangping] Hunan Inst Anim & Vet Sci, Vet Drug Lab, Changsha, Hunan, Peoples R China.

[Wu, Yong; Cheng, Xiaojun; Xiao, Gang; Sun, Zhiliang] Hunan Engn Res Ctr Vet Drug, Changsha, Hunan, Peoples R China.

[Wang, Yang] China Agr Univ, Coll Vet Med, Beijing, Peoples R China.

通讯机构：

[Sun, Zhiliang] H

Hunan Agr Univ, Coll Vet Med, Changsha, Hunan, Peoples R China.

Hunan Engn Res Ctr Vet Drug, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Aeromonas hydrophila;colistin resistance;EnvZ/OmpR;gene3832;mlaF

期刊：

Antimicrobial Agents and Chemotherapy

ISSN：

0066-4804

年：

2021

卷：

期：

页码：

e0007121

DOI：

10.1128/AAC.00071-21

基金类别：

We thank Xiaofeng Zheng, Zhaoying Liu, and Zhihang Yuan for valuable assistance with whole-genome sequencing. This work was supported by the National Key Research and Development Program of China (grant number 2017YFD0501403).

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Aeromonas hydrophila, a heterotrophic and Gram-negative bacterium, has attracted considerable attention owing to the increasing prevalence of reported infections. Colistin is a last-resort antibiotic that can treat life-threatening infections caused by multidrug-resistant Gram-negative bacteria. However, the mechanisms underlying colistin resistance in A. hydrophila remain unclear. The present study reveals four novel colistin resistance mechanisms in A. hydrophila: (i) EnvZ/OmpR upregulates the expression of the arnBCADTEF operon to mediate li...

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Various novel colistin resistance mechanisms interact to facilitate adaptation of aeromonas hydrophila to complex colistin environments

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