[ Objective ] The aim was to detect the toxicity of different kinds of plasticizers to organism. [ Method ] Under the condition of labo- ratory simulation, by measuring the biomass of microorganism (Isaria sp), soybean seed germination rate and bud length, the earthworm sur- vival rate and body length, studied the toxicity of three plasticizer to organism. [ Result ] The results indicate that the toxicity of three plastici- zers to Isaria sp was: Epoxidized Soybean Oil 〉 Acetyl Tributyl Citrate 〉 Di-n-octyl Phthalate. DOP shows obvious tox...