期刊论文

De Blanco, Esperanza Carcache

英文

ANTICANCER RESEARCH

0250-7005

2017

37

6

2839-2843

10.21873/anticanres.11635

We greatly acknowledge the financial support from the College of Pharmacy, The Ohio State University and the China Scholarship Council Program for providing financial support for Dr. Zhonghai Tang.

本校为其他机构

Background/Aim: Cancer is a leading cause of death. Hence, this study aimed at the optimization of niclosamide derivatives for the development of new potential anticancer agents. Materials and Methods: Niclosamide derivatives were synthesized and tested against a panel of human cancer cells: MDA and MCF7 breast cancer cells, PC3 and DU-145 prostate cancer cells, Hela cervical cancer cells, and HL-60 acute promyelocytic leukemia cells. They were also tested in nuclear factor-kappa appa B (NF kappa B), V-Ki-ras2 Kirsten rat sarcoma viral oncogene (KRAS), and mitochondria transmembrane potential ...