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Betulinic Acid Ameliorates the T-2 Toxin-Triggered Intestinal Impairment in Mice by Inhibiting Inflammation and Mucosal Barrier Dysfunction through the NF-κB Signaling Pathway

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成果类型:
期刊论文
作者:
Luo, Chenxi;Huang, Chenglong;Zhu, Lijuan;Kong, Li;Yuan, Zhihang;...
通讯作者:
Wu, Jing;Yi, Jine
作者机构:
[Wu, Jing; Huang, Chenglong; Luo, Chenxi; Li, Rongfang; Zhu, Lijuan; Wen, Lixin; Yi, Jine; Kong, Li; Yuan, Zhihang; Wu, J] Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.
[Li, Rongfang; Wen, Lixin; Yi, Jine] Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Peoples R China.
通讯机构:
[Wu, J; Yi, JN; Yi, Jine] H
Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.
Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Peoples R China.
语种:
英文
关键词:
NF-κB signaling pathway;T-2 toxin;betulinic acid;intestine;oxidative damage
期刊:
TOXINS
ISSN:
2072-6651
年:
2020
卷:
12
期:
12
页码:
794-
基金类别:
Conceptualization, J.Y. and J.W.; methodology, C.L. and C.H.; software, L.Z. and L.K.; validation, C.L., C.H. and L.Z.; formal analysis, Z.Y. and L.W.; investigation, J.W., R.L. and J.Y.; resources, J.Y. and J.W.; data curation, J.Y. and C.L.; writing—original draft preparation, C.L., C.H. and L.Z.; writing—review and editing, J.Y. and L.Z.; visualization, J.W.; supervision, J.Y. and J.W.; project administration, J.Y. and J.W.; funding acquisition, J.Y. All authors have read and agreed to the published version of the manuscript. The research was funded by the Natural Science Foundation of Hunan Province, China (Grant No. 2020JJ4368), “Double First-Class” Disciplinary Construction Project of Hunan Agricultural University (SYL2019049) and Innovation Research and Development Project of the Hunan Development and Reform Commission (37).
机构署名:
本校为第一且通讯机构
院系归属:
动物医学院
摘要:
T-2 toxin, a trichothecene mycotoxin produced by Fusarium, is widely distributed in crops and animal feed and frequently induces intestinal damage. Betulinic acid (BA), a plant-derived pentacyclic lupane-type triterpene, possesses potential immunomodulatory, antioxidant and anti-inflammatory biological properties. The current study aimed to explore the protective effect and molecular mechanisms of BA on intestinal mucosal impairment provoked by acute exposure to T-2 toxin. Mice were intragastrically administered BA (0.25, 0.5, or 1 mg/kg) daily for 2 weeks and then injected intraperitoneally w...

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