Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors

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成果类型：

期刊论文

作者：

Wang, Jin;Sun, Liang-Fei;Cui, Wen-Wen;Zhao, Wen-Shan;Ma, Xue-Fei;...

通讯作者：

Yu, Ye;Tian, Yun

作者机构：

[Sun, Liang-Fei; Hu, You-Min; Ma, Xue-Fei; Yang, Yang; Cui, Wen-Wen; Liu, Yan; Zhao, Wen-Shan; Li, Bin; Wang, Jin; Yu, Ye; Cheng, Xiao-Yang; Huang, Li-Dong] Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Dept Pharmacol & Chem Biol, Shanghai 200025, Peoples R China.

[Sun, Liang-Fei; Hu, You-Min; Ma, Xue-Fei; Yang, Yang; Cui, Wen-Wen; Liu, Yan; Zhao, Wen-Shan; Li, Bin; Wang, Jin; Yu, Ye; Cheng, Xiao-Yang; Huang, Li-Dong] Shanghai Jiao Tong Univ, Sch Med, Shanghai Tongren Hosp, Hongqiao Int Inst Med, Shanghai 200025, Peoples R China.

[Tian, Yun; Ma, Xue-Fei; Lu, Xiang-Yang; Li, Bin; Yu, Ye; Tian, Y] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

[Li, Lingyong] Univ Texas MD Anderson Canc Ctr, Dept Anesthesiol & Perioperat Med, Houston, TX 77030 USA.

通讯机构：

[Yu, Ye] S

[Tian, Y; Yu, Y] H

Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Dept Pharmacol & Chem Biol, Shanghai 200025, Peoples R China.

Shanghai Jiao Tong Univ, Sch Med, Shanghai Tongren Hosp, Hongqiao Int Inst Med, Shanghai 200025, Peoples R China.

Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

*P2X receptors;*conformational change;*gating;*ion channel;*molecular simulations;*physical couplings;*protein domain;*receptor structure-function;*single channel recording

期刊：

Journal of Biological Chemistry

ISSN：

0021-9258

年：

2017

卷：

292

期：

页码：

7619-7635

DOI：

10.1074/jbc.M116.771121

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31570832, 31170787, 31400707]; National Program on Key Basic Research Project of ChinaNational Basic Research Program of China [2014CB910302]; National Excellent Young Scientist Foundation of China [31222018]; Science and Technology Fund of Shanghai Jiao Tong University School of Medicine Grant [13XJ10042]; Opening Project of State Key Laboratory of Drug Research Grant [SIMM1601KF-02]; Doctoral Innovation Fund Projects from Shanghai Jiao Tong University School of Medicine Grant [BXJ201405]

机构署名：

本校为通讯机构

院系归属：

生物科学技术学院

摘要：

P2X receptors are ATP-gated trimeric channels with important roles in diverse pathophysiological functions. A detailed understanding of the mechanism underlying the gating process of these receptors is thus fundamentally important and may open new therapeutic avenues. The left flipper (LF) domain of the P2X receptors is a flexible loop structure, and its coordinated motions together with the dorsal fin (DF) domain are crucial for the channel gating of the P2X receptors. However, the mechanism underlying the crucial role of the LF domain in the channel gating remains obscure. Here, we propose t...

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Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors

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