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High-accuracy splice site prediction based on sequence component and position features

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成果类型:
期刊论文
作者:
Li, J. L.;Wang, L. F.;Wang, H. Y.;Bai, L. Y.;Yuan, Z. M.*
通讯作者:
Yuan, Z. M.
作者机构:
[Wang, L. F.; Yuan, Z. M.; Li, J. L.] Hunan Agr Univ, Hunan Prov Key Lab Crop Germplasm Innovat & Utili, Changsha, Hunan, Peoples R China.
[Yuan, Z. M.; Li, J. L.; Bai, L. Y.] Hunan Agr Univ, Coll Biosafety Sci & Technol, Changsha, Hunan, Peoples R China.
[Wang, H. Y.] Kansas State Univ, Dept Stat, Manhattan, KS 66506 USA.
通讯机构:
[Yuan, Z. M.] H
Hunan Agr Univ, Hunan Prov Key Lab Crop Germplasm Innovat & Utili, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
Adjacent position relationship features;Multi-scale component features;Position features;Splice site prediction;Support vector machine
期刊:
Genetics and Molecular Research
ISSN:
1676-5680
年:
2012
卷:
11
期:
3
页码:
3431-3451
基金类别:
Science Foundation for Distinguished Young Scholars of Hunan Province, ChinaNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [10JJ1005]; Research Fund for the Doctoral Program of Higher Education of ChinaResearch Fund for the Doctoral Program of Higher Education of China (RFDP)Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [200805370002]
机构署名:
本校为第一且通讯机构
院系归属:
植物保护学院
摘要:
Identification of splice sites plays a key role in the annotation of genes. Consequently, improvement of computational prediction of splice sites would be very useful. We examined the effect of the window size and the number and position of the consensus bases with a chi-square test, and then extracted the sequence multi-scale component features and the position and adjacent position relationship features of consensus sites. Then, we constructed a novel classification model using a support vector machine with the previously selected features an...

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