Dietary alpha-ketoglutarate supplementation may increase muscle gain through mTOR signaling pathway in diet-induced obese rat

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成果类型：

期刊论文

作者：

Yao, K.;Xiong, X.;Fu, C.;Dahanayaka, S.;Lei, J.;...

作者机构：

Chinese Acad. Sci., Inst. Subtrop. Agr., Res. Ctr Healthy Breeding Livestock and Poultry, Hunan Engn and Res. Ctr Anim. and Poultry Sci., Key Lab Agroecol. Proc. Subtrop. Reg, Furong Road #644, Changsha City, Hunan 410125, China

Department of Animal Science, Texas A and M University, College Station, TX 77843, United States

Department of Agricultural Leadership, Education and Communications, Texas A and M University, College Station, TX 77843, United States

College of Animal Science and Technology, Hunan Agricultural University, Nongda Road #1, Changsha City, Hunan 410128, China

语种：

英文

关键词：

Fat;Muscle;mTOR signaling;α-ketoglutarate

期刊：

Journal of Food, Agriculture and Environment

ISSN：

1459-0255

年：

2013

卷：

期：

3-4

页码：

151-154

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

摘要：

Obesity is a major public health crisis worldwide. This study was conducted to test the beneficial effect of α-ketoglutarate (α-KG) in obesity objects. Male Sprague-Dawley rats were fed for 15 wk a high-fat (40% energy) diet beginning at 4 wk of age, resulting in 30% higher body weight gains higher weights in HF than normal fed rats. Starting at 19 wk of age, the rats continued to be fed their diets and receive drinking water containing 0 or 1% α-KG (n = 8 per group) for 10 weeks. Water consumption was measured daily. Food intake and body we...

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Dietary alpha-ketoglutarate supplementation may increase muscle gain through mTOR signaling pathway in diet-induced obese rat

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