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Inhibitor of Apoptosis Protein-Like Protein-2 as a Novel Serological Biomarker for Breast Cancer

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成果类型:
期刊论文
作者:
Xiang, Mingjun*;Zhou, Wei;Gao, Dandan;Fang, Xiansong;Liu, Qian
通讯作者:
Xiang, Mingjun
作者机构:
[Xiang, Mingjun] Jishou Univ, Dept Biochem & Mol Biol, Coll Med Sci, Jishou 416000, Peoples R China.
[Liu, Qian; Xiang, Mingjun] Gannan Med Univ, Dept Biochem & Mol Biol, Ganzhou 341000, Peoples R China.
[Zhou, Wei] Hunan Agr Univ, Hunan Prov Key Lab Biol & Control Plant Dis & Ins, Coll Biosafety Sci & Technol, Changsha 410128, Hunan, Peoples R China.
[Gao, Dandan] Chinese Acad Med Sci, Inst Med Biol, Kunming 650118, Peoples R China.
[Fang, Xiansong] Gannan Med Univ, Affiliated Hosp 1, Clin Lab, Ganzhou 341000, Peoples R China.
通讯机构:
[Xiang, Mingjun] J
Jishou Univ, Dept Biochem & Mol Biol, Coll Med Sci, Jishou 416000, Peoples R China.
语种:
英文
关键词:
ILP-2;breast cancer;serological biomarker
期刊:
International Journal of Molecular Sciences
ISSN:
1422-0067
年:
2012
卷:
13
期:
12
页码:
16737-16750
基金类别:
Scientific Research Fund of Jiangxi Provincial Education Department of China [GJJ10571]; Jiangxi Provincial Natural Science Foundation of China [2010GZY0007]; Jishou University of China [jsdxrcyjkyxm201109]; Scientific Research Fund of Hunan Provincial Education Department of ChinaHunan Provincial Education Department [12A112]; Key project of Jiangxi Medical Science and technology development Foundation [20094013, GJJ10028]; Specialized Research Fund for the Doctoral Program of Higher Education of ChinaSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20114320120005]
机构署名:
本校为其他机构
院系归属:
植物保护学院
摘要:
Inhibitor of apoptosis protein-like protein-2 (ILP-2) has only been detected in the testis and in lymphoblastoid cells. Although previous studies have not reported the presence of ILP-2 in breast cancer tissues, this study indicates the presence of ILP-2 in breast cancer serum samples. To validate whether ILP-2 is a novel serological biomarker for breast cancer, we conducted two-dimensional gel electrophoresis (2DE) and matrix-assisted laser desorption/ionization-time of flight mass spectrometry analysis on 400 breast cancer serum samples and 40 non-cancer serum samples (i.e., healthy controls...

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