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Histone acetyltransferase inhibitors antagonize AMP-activated protein kinase in postmortem glycolysis

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成果类型:
期刊论文
作者:
Li, Qiong;Li, Zhongwen;Lou, Aihua;Wang, Zhenyu;Zhang, Dequan*;...
通讯作者:
Shen, Qingwu W.;Zhang, Dequan
作者机构:
[Shen, Qingwu W.; Lou, Aihua; Li, Qiong] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Hunan, Peoples R China.
[Zhang, Dequan; Li, Zhongwen; Wang, Zhenyu] Chinese Acad Agr Sci, Key Lab Agroprod Proc, Minist Agr, Inst Food Sci & Technol, Beijing 100193, Peoples R China.
通讯机构:
[Shen, Qingwu W.] H
[Zhang, Dequan] C
Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Hunan, Peoples R China.
Chinese Acad Agr Sci, Key Lab Agroprod Proc, Minist Agr, Inst Food Sci & Technol, Beijing 100193, Peoples R China.
语种:
英文
关键词:
AMP-activated Protein Kinase (AMPK);Pale, Soft, Exudative (PSE);Postmortem Glycolysis;Protein Acetylation
期刊:
ANIMAL BIOSCIENCE
ISSN:
2765-0189
年:
2017
卷:
30
期:
6
页码:
857-864
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31571862]; Agricultural Science and Technology Innovation Program
机构署名:
本校为第一且通讯机构
院系归属:
食品科学技术学院
摘要:
Objective: The purpose of this study was to investigate the influence of AMP-activated protein kinase (AMPK) activation on protein acetylation and glycolysis in postmortem muscle to better understand the mechanism by which AMPK regulates postmortem glycolysis and meat quality. Methods: A total of 32 mice were randomly assigned to four groups and intraperitoneally injected with 5-Aminoimidazole-4-carboxamide1-β-D-ribofuranoside (AICAR, a specific activator of AMPK), AICAR and histone acetyltransferase inhibitor II, or AICAR, Trichostatin A (TSA...

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