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Fumonisin B-1 Induces Oxidative Stress and Breaks Barrier Functions in Pig Iliac Endothelium Cells

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成果类型:
期刊论文
作者:
Yuan, Qiaoling;Jiang, Yancheng;Fan, Ying;Ma, Yingfeng;Lei, Hongyu*;...
通讯作者:
Su, Jianming;Lei, Hongyu
作者机构:
[Yuan, Qiaoling; Su, Jianming] Hunan Agr Univ, Dept Basic Vet Med, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.
[Ma, Yingfeng; Fan, Ying; Lei, Hongyu; Jiang, Yancheng] Hunan Agr Univ, Dept Vet Prevent Med, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.
通讯机构:
[Su, Jianming; Lei, Hongyu] H
Hunan Agr Univ, Dept Basic Vet Med, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.
Hunan Agr Univ, Dept Vet Prevent Med, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.
语种:
英文
关键词:
Fumonisin B-1;pig iliac endothelial cells;oxidative stress;tight junction
期刊:
TOXINS
ISSN:
2072-6651
年:
2019
卷:
11
期:
7
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31571432]; 2011 Collaborative Innovation Center of Hunan Province for Livestock Safety Production
机构署名:
本校为第一且通讯机构
院系归属:
动物医学院
摘要:
Fumonisins (Fums) are types of mycotoxin that widely contaminante feed material crops, and can trigger potential biological toxicities to humans and various animals. However, the toxicity of Fums on porcine blood vessels has not been fully explored. Fumonisin B1 (FB1) is the main component of Fums. Therefore, the aim of this study was to explore the effects of FB1 on the oxidative stress and tight junctions of the pig iliac endothelial cells (PIECs) in vitro. The results showed that FB1 reduced the viability of PIECs, increased the contents of ...

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