Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-kappa B Pathway

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成果类型：

期刊论文

作者：

Wu, Jing;Yang, Cheng-Lin;Sha, Yuan-Kun;Wu, Yong;Liu, Zhao-Ying;...

通讯作者：

Yuan, Zhi-Hang;Sun, Zhi-Liang

作者机构：

[Wu, Jing; Wu, Yong; Sun, Zhi-Liang; Sha, Yuan-Kun; Liu, Zhao-Ying; Yuan, Zhi-Hang; Yang, Cheng-Lin] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Wu, Jing; Wu, Yong; Sun, Zhi-Liang; Sha, Yuan-Kun; Liu, Zhao-Ying; Yuan, Zhi-Hang; Yang, Cheng-Lin] Hunan Agr Univ, Hunan Collaborat Innovat Utilizat Bot Funct Ingre, Changsha 410128, Hunan, Peoples R China.

[Wu, Yong; Sun, Zhi-Liang; Liu, Zhao-Ying; Yuan, Zhi-Hang] Hunan Agr Univ, Hunan Engn Res Ctr Vet Drug, Changsha 410128, Hunan, Peoples R China.

[Yuan, Zhi-Hang; Sun, ZL] HAU, Coll Vet Med, 1 Nongdalu Rd, Changsha 100071, Hunan, Peoples R China.

通讯机构：

[Yuan, ZH; Sun, ZL] H

HAU, Coll Vet Med, 1 Nongdalu Rd, Changsha 100071, Hunan, Peoples R China.

语种：

英文

关键词：

IPEC-J2 Cells;Intestinal Barrier Dysfunction;Koumine;LPS;Nrf2/NF-kappaB Pathway

期刊：

AMERICAN JOURNAL OF CHINESE MEDICINE

ISSN：

0192-415X

年：

2020

卷：

期：

页码：

127-142

DOI：

10.1142/S0192415X2050007X

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31572563, 31802238]; Scientific Research Project of Hunan Provincial Education Department [17B125, 17C0765]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2017M620346]; National Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [2019JJ50272]

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

Gelsemium elegans Benth. (G. elegans), a traditional Chinese medicine, has great potential as an effective growth promoter in animals, however, the mechanism of its actin remains unclear. Here, we evaluated the protective effects of koumine extract from G. elegans against lipopolysaccharide (LPS)-induced intestinal barrier dysfunction in IPEC-J2 cells through alleviation of inflammation and oxidative stress. MTT and LDH assays revealed that koumine significantly reduced LPS cytotoxicity. Transepithelial electrical resistance (TEER) and cell monolayer permeability assays showed that koumine tr...

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Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-kappa B Pathway

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