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Lactobacillus plantarum attenuates glucocorticoid-induced osteoporosis by altering the composition of rat gut microbiota and serum metabolic profile

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成果类型:
期刊论文
作者:
Li, Siying;Han, Xuebing;Liu, Naiyuan;Chang, Jiang;Liu, Gang;...
通讯作者:
Hu, SW;Liu, G
作者机构:
[Hu, Siwang; Hu, SW; Li, Siying; Chang, Jiang] Wenzhou Med Univ, Peoples Hosp Wenling 1, Wenling Hosp, Orthopaed Ctr, Wenzhou, Zhejiang, Peoples R China.
[Liu, Gang; Han, Xuebing; Liu, Naiyuan; Li, Siying; Liu, G] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha, Hunan, Peoples R China.
通讯机构:
[Hu, SW ] W
[Liu, G ] H
Wenzhou Med Univ, Peoples Hosp Wenling 1, Wenling Hosp, Orthopaed Ctr, Wenzhou, Zhejiang, Peoples R China.
Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
L. plantarum;dexamethasone;differential metabolites;food active ingredients;glucocorticoids;gut microbes;osteoporosis;probiotics
期刊:
FRONTIERS IN IMMUNOLOGY
ISSN:
1664-3224
年:
2024
卷:
14
页码:
1285442
基金类别:
Zhejiang Provincial Program for Medicine and Health [2022KY446, 2022KY447, 2023KY1345, 2023KY1347]; Social Development Science and Technology Foundation of Taizhou [21ywb118, 20ywb143]; Social Development Science and Technology Foundation of Wenling [2020S0180083, 2021S00156, 2020S0180127]
机构署名:
本校为通讯机构
院系归属:
生物科学技术学院
摘要:
INTRODUCTION: Osteoporosis, one of the most common non-communicable human diseases worldwide, is one of the most prevalent disease of the adult skeleton. Glucocorticoid-induced osteoporosis(GIOP) is the foremost form of secondary osteoporosis, extensively researched due to its prevalence.Probiotics constitute a primary bioactive component within numerous foods, offering promise as a potential biological intervention for preventing and treating osteoporosis. This study aimed to evaluate the beneficial effects of the probiotic Lactobacillus plantarum on bone health and its underlying mechanisms ...

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