Gymnemic acid I triggers mechanistic target of rapamycin-mediated β cells cytoprotection through the promotion of autophagy under high glucose stress

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成果类型：

期刊论文

作者：

Wu, Yanyang;Hu, Yongquan;Yuan, Yuju;Luo, Yushuang;Lai, Dengni;...

通讯作者：

Liu, Dongbo

作者机构：

[Liu, Dongbo; Yuan, Yuju; Wu, Yanyang; Lai, Dengni] Hunan Agr Univ, Changsha 410128, Hunan, Peoples R China.

[Zhou, Haiyan; Liu, Dongbo; Yuan, Yuju; Hu, Yongquan; Wu, Yanyang; Lai, Dengni; Luo, Yushuang] Hunan Agr Univ, Hort & Landscape Coll, Changsha, Hunan, Peoples R China.

[Yuan, Yuju; Wu, Yanyang; Lai, Dengni] Hunan Agr Univ, Coll Food Sci & Technol, Changsha, Hunan, Peoples R China.

[Zhou, Haiyan; Liu, Dongbo; Hu, Yongquan; Luo, Yushuang] Hunan Coinnovat Ctr Utilizat Bot Funct Ingredient, Changsha, Hunan, Peoples R China.

[Zhou, Haiyan; Liu, Dongbo; Hu, Yongquan; Luo, Yushuang] State Key Lab Subhlth Intervent Technol, Changsha, Hunan, Peoples R China.

通讯机构：

[Liu, Dongbo] H

Hunan Agr Univ, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

antidiabetic agent;caspase 3;glucose;gymnemic acid 1;mammalian target of rapamycin;ribosomal protein s6 kinase beta 1;S6 kinase;unclassified drug;glucose;gymnemic acid;saponin;target of rapamycin kinase;triterpene;apoptosis;Article;autophagosome;autophagy;cell protection;comparative study;controlled study;drug design;drug mechanism;enzyme activity;flow cytometry;glucose stress;glucotoxicity;Gymnema sylvestre;immunofluorescence;pancreas islet beta cell;priority journal;protein phosphorylation;stress;Western blotting;animal;autophagy;chemistry;drug effect;metabolism;mouse;pancreas islet beta cell;pathology;phosphorylation;tumor cell line;Animals;Autophagy;Cell Line, Tumor;Cytoprotection;Glucose;Insulin-Secreting Cells;Mice;Phosphorylation;Saponins;TOR Serine-Threonine Kinases;Triterpenes

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2019

卷：

234

期：

页码：

9370-9377

DOI：

10.1002/jcp.27621

基金类别：

This study was supported by the National Natural Science Foundation of China (Grant Nos. 31601125 and 81501708), the Foundation of Science and Technology Talents at Hunan Agriculture University (Grant No. 13YJ07) and the Major Science and Technology Special Projects of Hunan Province (Grant No. 2017SK1020). National Natural Science Foundation of China, Grant/Award Number: 31601125; National Natural Science Foundation of China, Grant/ Award Number: 81501708; National Natural Science Foundation of Hunan Province; Major Science and Technology Special Projects of Hunan Province, Grant/Award Number: 2017SK1020; Natural Science Foundation of Hunan Agricutral University; Foundation of Science and Technology Talents at Hunan Agriculture University

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

食品科学技术学院

摘要：

Gymnemic acid I (GA I) is a bioactive component of Gymnema sylvestre. It is an Indian traditional medicinal herb which has antidiabetic effect. However, the molecular mechanism is remaining to be elucidated. Here, we showed that high glucose promoted the rate of apoptosis, GA I decreased the apoptosis under the high glucose stress. Our further study explored that GA I increased the number of autophagosome and the ratio of light chain 3-I (LC3-I)/LC3-II in MIN-6 cells under the normal or high glucose stress by the methods of western blot analysi...

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Gymnemic acid I triggers mechanistic target of rapamycin-mediated β cells cytoprotection through the promotion of autophagy under high glucose stress

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